Contemporary manifestations of human biological «insufficiency» and prospects of progress in medicine

Philosophy

Authors

  • Oleg Alexandrovich Barg Perm State University, 15, Bukirev st., Perm, 614990, Russia
  • Anton Igorevich Zhelnin Perm State University, 15, Bukirev st., Perm, 614990, Russia

DOI:

https://doi.org/10.17072/2078-7898/2017-2-183-189

Keywords:

biological insufficiency, non-communicable disease, medicalization, medicine, health, epigenetics, aging, stress

Abstract

The article considers modern biological manifestations of human insufficiency and ways to overcomethem. The global epidemic of non-communicable diseases, which significantly reduces both lifespan and quality of life, is supposed to be the fundament of modern human biological insufficiency. It is shown that in spiteof the modern advances in biomedical technology, medicine is far from the full implementation of its regenerative direction, clinical application of epigenomics and biogerontology. Non-communicable diseases are extremely complex in their nature, but, at the same time, the majority of them are strongly determined by the lifestyle. Nowadays active medicalization of lifestyle is taking place. This process cannot be evaluated only asnegative: it means the increasing consciousness of people in regard to their health. In the situation of «inhibition» of new technologies’ introduction into clinical practice, the main line of overcoming the global epidemic should be connected with the rapid development of predictive and preventive forms of medicine, which is an example of the need for the society’s movement towards conscious management of its biology. 

Author Biographies

Oleg Alexandrovich Barg , Perm State University, 15, Bukirev st., Perm, 614990, Russia

Doctor of Philosophy, Docent,Professor of the Department of Philosophy

Anton Igorevich Zhelnin , Perm State University, 15, Bukirev st., Perm, 614990, Russia

Ph.D. in PhilosophySenior Lecturer of the Department of Philosophy

References

Лисицын Ю.П. Общественное здоровье и здравоохранение. М.: ГЭОТАР-Медиа, 2010. 502 с.

Daar A.S. et al. Grand challenges in chronic non-communicable diseases // Nature.

Collins P.Y. et al. Grand challenges in global mental health // Nature.

Reiche E.M.V., Nunes S.O.V., Morimoto H.K. Stress, depression, the immune system, and cancer // The lancet oncology. 2004. Vol. 5, № DOI:

Beaglehole R. et al. Priority actions for the non-communicable disease crisis // The Lancet. .

Лебедев В.Ю., Федоров А.В. Медикализация современной культуры: ментальные и социобиологические аспекты // Вестник Тверского государственного университета. Серия: Философия. 2016. № 2. С. 47–64.

Михель Д.В. Медикализация как социальный феномен // Вестник Саратовского государственного технического университета. 2011. № 4(60), вып. 2. С. 256–263.

Камалиева И.Р. Трансформация социальной нормы в условиях прогресса биотехнологий // Исторические, философские, политические и юридические науки, культурология и искусствоведение. Вопросы теории и практики. 2015. № 10–3(50). С. 80–83.

Тищенко П.Д., Юдин Б.Г. Социогуманитарное сопровождение инновационных проектов в биомедицине // Знание. Понимание. Умение. 2016. № 2. С. 73–86. DOI: 10.17805/zpu.2016.2.7.

Qureshi I.A., Mehler M.F. Advances in epigenetics and epigenomics for neurodegenerative diseases // Current neurology and neuroscience reports. 2011. Vol. 11, №DOI: 10.1007/s11910-011-0210-2.

Herceg Z., Vaissière T. Epigenetic mechanisms and cancer: an interface between the environment and the genome // Epigenetics. 2011. Vol. 6, iss. 7. P. 804–819.DOI: 10.4161/epi.6.7.16262.

Finch C.E., Tanzi R.E. Genetics of aging // Science. 1997. Vol. 278, no. 5337. P. 407–411.

Анисимов В.Н. Молекулярные и физиологические механизмы старения. СПб.: Наука, 2003. 468 с.

Скулачев В.П. Феноптоз: запрограммированная смерть организма // Биохимия. 1999. Т. 64, № 12. С. 1679–1688.

Baynes J.W. From life to death — the struggle between chemistry and biology during aging: the Maillard reaction as an amplifier of genomic damage // Biogerontology. 2000. Vol. 1, №

Барг О.А. Живое в едином мировом процессе. Пермь: Изд-во Перм. ун-та, 1993. 227 с.

Изуткин Д.А., Галочкина Н.Е. «Принцип маятника» в философии нормы и патологии // Гуманитарный вектор. Серия: Философия, культурология. 2016. Т. 11, № 1. С. 23–27.

Величковский Б.Т. Социальный стресс, трудовая мотивация и здоровье // Профилактическая и клиническая медицина. 2005. № 2. С. 7–18.

Marmot M. Status syndrome: how your social standing directly affects your health and life. London: Bloomsbury, 2004. 319 p.

Агаджанян Н.А., Чижов А.Я., Ким Т.А. Болезни цивилизации // Экология человека. 2003. № 4. С. 8–11.

References

Lisitsyn Yu.P. Obschestvennoe zdorov’e i zdravookhranenie [Public Health and Health Service]. Moscow, GEOTAR-Media Publ., 2010, 502 p. (In Russian)

. 2. Daar A.S. et al. Grand Challenges in Chronic NonCommunicable Diseases. Nature. 2007, vol. 450, no. 7169, pp. 494–496. (In English).

Collins P.Y. et al. Grand Challenges in Global Mental Health. Nature. 2011, vol. 475, no. 7354, pp. 27–30. (In English).

Reiche E.M.V., Nunes S.O.V., Morimoto H.K. Stress, Depression, the Immune system, and Cancer. The Lancet Oncology. 2004, vol. 5, no. 10, pp. 617– 625. DOI: 10.1016/S1470-2045(04)01597-9. (In English).

Beaglehole R. et al. Priority Actions for the NonCommunicable Disease Crisis. The Lancet. 2011, vol. 377, no. 9775, pp. 1438–1447. DOI: 10.1016/S0140-6736(11)60393-0. (In English).

Lebedev V.Yu., Fedorov A.V. Medikalizatsiya sovremennoy kul’tury: mental’nye i sotsiobiologicheskie aspekty [Medicalization of Contemporary Culture: Mental and Socio-Biological Aspects]. Vestnik Tverskogo gosudarstvennogo universiteta. Seriya: Filosofiya [Herald of Tver State University. Series: Philisophy]. 2016, no. 2, pp. 47–64. (In Russian).

Mikhel D.V. Medikalizatsiya kak sotsial’niy fenomen [Medicalization as Social Phenomenon]. Vestnik Saratovskogo gosudarstvennogo tekhnicheskogo universiteta [Vestnik Saratov State Technical University]. 2011, no. 4(60), iss. 2, pp. 256– 263. (In Russian).

Kamalieva I.R. Transformatsiya sotsial’noy normy v usloviyakh progressa biotekhnologiy [Transformation of Social Norm in the Conditions of Biotechnologies Progress]. Istoricheskie, filosofskie, politicheskie i yuridicheskie nauki, kul’turologiya i iskusstvovedenie. Voprosy teorii i praktiki [Historical, Philosophical, Political and Law Sciences, Culturology and Study of Art. Issues of Theory and Practice]. 2015, no. 10–3(50), pp. 80– 83. (In Russian).

Tischenko P.D., Yudin B.G. Sotsiogumanitarnoe soprovozhdenie innovatsionnykh proektov v biomeditsine [Social and Humanitarian Support of Innovative Biomedical Projects]. Znanie. Ponimanie. Umenie [Knowledge. Understanding. Skill]. 2016, no. 2, pp. 73–86. DOI: 10.17805/zpu.2016.2.7. (In Russian).

Qureshi I.A., Mehler M.F. Advances in Epigenetics and Epigenomics for Neurodegenerative Diseases. Current Neurology and Neuroscience Reports. 2011, vol. 11, no. 5, pp. 464–473. DOI: 10.1007/s11910-011-0210-2. (In English).

Herceg Z., Vaissière T. Epigenetic Mechanisms and Cancer: an Interface Between the Environment and the Genome. Epigenetics. 2011, vol. 6, no. 7, pp. 804–819. DOI: 10.4161/epi.6.7.16262. (In English).

Finch C.E., Tanzi R.E. Genetics of Aging. Science. 1997, vol. 278, no. 5337, pp. 407–411.

Anisimov V.N. Molekulyarnye i fiziologicheskie mekhanizmy stareniya [Molecular and Physiological Mechanisms of Aging]. Saint Petersburg, Nauka Publ., 2003, 468 p. (In Russian).

Skulachev V.P. Fenoptoz: zaprogrammirovannaya smert’ organizma [Phenoptosis: Programmed Death of an Organism]. Biokhimiya [Biochemistry]. 1999, vol. 64, no. 12, pp. 1679–1688. (In Russian).

Baynes J.W. From Life to Death — the Struggle Between Chemistry and Biology During Aging: the Maillard Reaction as an Amplifier of Genomic Damage. Biogerontology. 2000, vol. 1, no. 3, pp. 235–246. (In English).

Barg O.A. Zhivoe v edinom mirovom protsesse [Living in United World Process]. Perm, Perm State University Publ., 1993, 227 p. (In Russian).

Izutkin D.A., Galochkina N.E. «Printsip mayatnika» v filosofii normy i patologii [«Principle of Pendulum» in Normal and Pathological Philosophy]. Gumanitarnyy vektor. Seriya Filosofiya, kulturologiya [Humanitarian Vector. Series Philosophy, Culturology]. 2016, vol. 11, no. 1, pp. 23–27. (In Russian).

Velichkovskiy B.T. Sotsial’nyy stress, trudovaya motivatsiya i zdorov’e [Social Stress, Labor Motivation and Health]. Profilakticheskaya i klinicheskaya meditsina [Preventive and Clinical Medicine]. 2005, no. 2, pp. 7–18. (In Russian).

Marmot M. Status Syndrome: How Your Social Standing Directly Affects Your Health and Life. London, Bloomsbury Publ., 2004, 319 p. (In English).

Agadzhanyan N.A., Chizhov A.Ya., Kim T.A. Bolezni tsivilizatsii [Diseases of Civilization]. Ekologiya cheloveka [Ecology of the Human]. 2003, no. 4, pp. 8–11. (In Russian).

Published

2017-06-30

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