HORMONE REGULATION OF CELLS DIFFERENTIATION IN THYMUS AT PREGNANCY (REVIEW)

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Published: Oct 25, 2018
Keywords:
estriol human chorionic gonadotropin leptin ghrelin kisspeptin subpopulations of t-lymphocytes dendritic cells pregnancy thymocyte

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Екатерина Григорьевна Орлова
Institute of Ecology and Genetics of Microorganism HB RAS
Сергей Викторович Ширшев
Institute of Ecology and Genetics of Microorganism HB RAS;
Ирина Валерьевна Некрасова
Institute of Ecology and Genetics of Microorganism HB RAS
Ольга Леонидовна Горбунова
Institute of Ecology and Genetics of Microorganism HB RAS
Ирина Леонидовна Масленникова
Institute of Ecology and Genetics of Microorganism HB RAS
Ольга Александровна Логинова
Institute of Ecology and Genetics of Microorganism HB RAS

Abstract

The thymus is the central organ of immunity, where the formation of the major effector and regulatory T-lymphocytes subpopulations. Pregnancy accompanied with steroid-induced involution of the thymus. Such hormone-dependent involution of the thymus was observed also under stress, ageing, a number of autoimmune diseases. During pregnancy the placenta produces a lot of biologically active substances including hormones (estriol, human chorionic gonadotropin, kisspeptin, leptin, ghrelin, etc.) with immuno-modulating activity. However, the mechanisms of hormonal regulation of lymphocyte differentiation at thymus in the aspect of pregnancy remained scarcely explored. The review analysed data from literature and the results of our research on the role of hormones produced by the placenta, in the regulation of main subpopulations of lymphocytes, dendritic cell function, differentiation at thymus and immune tolerance formation.

Article Details

How to Cite
Орлова, Е. Г., Ширшев, С. В., Некрасова, И. В., Горбунова, О. Л., Масленникова, И. Л., & Логинова, О. А. (2018). HORMONE REGULATION OF CELLS DIFFERENTIATION IN THYMUS AT PREGNANCY (REVIEW). Bulletin of Perm University. Biology, (4), 395–401. Retrieved from https://press.psu.ru/index.php/bio/article/view/1779
Issue
No. 4 (2016): Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology
Section
Клиническая лабораторная диагностика

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Author Biographies

Екатерина Григорьевна Орлова, Institute of Ecology and Genetics of Microorganism HB RAS

Doctor of biology, senior researcher of laboratory immunoregulation

Сергей Викторович Ширшев, Institute of Ecology and Genetics of Microorganism HB RAS;

Doctor of medical science, head of laboratory immunoregulation

Ирина Валерьевна Некрасова, Institute of Ecology and Genetics of Microorganism HB RAS

Candidate of biology, researcher of laboratory immunoregulation

Ольга Леонидовна Горбунова, Institute of Ecology and Genetics of Microorganism HB RAS

Candidate of biology, researcher of laboratory immunoregulation

Ирина Леонидовна Масленникова, Institute of Ecology and Genetics of Microorganism HB RAS

Candidate of biology, senior researcher of laboratory immunoregulation

Ольга Александровна Логинова, Institute of Ecology and Genetics of Microorganism HB RAS

Postgraduate

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Hardie L., Tray hum P. Circulating leptin in women: longitudinal study in menstrual cycle and during pregnancy. Clin. Endocrinol. V. 47 (1997): pp. 101-106.

Hubert P., Jacobs N., Caberg J.-H., Boniver J., Delvenne P. The cross-talk between dendritic and regulatory Tcells: good or evil? J. of Leukocyte Biol. V. 82 (2007): pp. 787-794.

Koldehoff M., Elmaagacli A.H. Thoughts on feto-maternal tolerance: is there a lesson to be learned from allogeneic haematopoietic stem cell transplantation? Cell Biol. Int. V. 37 (2013): pp. 766-767.

Liu, F. Guo J., Tian T. Placental trophoblasts shifted Thl/Th2 balance toward Th2 and inhibited Thl7 immunity at fetomaternal interface. APMIS. V. 119 No. 9 (2011): pp. 597-604.

Lutz M.B., Schuler G. Immature, semi-mature and fully mature dendritic cells: witch signals induce tolerance or immunity? Trends Immunol. V. 23 (2002): pp. 235-244.

Saito S., Nakashima A., Shima T., Ito M. Thl/Th2/Thl7 and regulatory T-cell paradigm in pregnancy. Am. J. Reprod. Immunol. V. 601 No. 63 (2010): pp. 601-610.

Tena-Sempere M. Roles of ghrelin and leptin in the control of reproductive function. Neuroendocri-nology. V. 86 (2007): pp. 229-241.

Vacca P., Moretta L., Moretta A., Mingari M.C. Origin, phenotype and function of human natural killer cells in pregnancy. Trends in Immunology. V. 32 No. 11 (2011): pp. 517-523.

Wegmann T. Lin H., Guilbert L., Mosmann T.R. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol. Today. V. 14 No. 7 (1993): pp. 353-356.

Zenclussen A.C. Adaptive immune responses during pregnancy. Am. J. Reprod. Immunol. V. 69 No. 4 (2013): pp. 291-303.

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