STUDY OF THE (+)-EROGORGIANE ANTIMICROBIAL ACTION MECHANISMS

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Published: Oct 25, 2018
Keywords:
erogorgiane antibiotic mycobacterium smegmatis biofilms

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Лариса/Larisa Юрьевна/Yurievna Нестерова/Nesterova
Institute of Ecology and Genetics of Microorganism UB RAS
Александр/Alexander Георгиевич/Georgievich Ткаченко/Tkachenko
Institute of Ecology and Genetics of Microorganism UB RAS; Perm State University
Ольга/Olga Николаевна/Nikolaevna Писцова/Pistsova
Perm State University

Abstract

The antibacterial activity of a chemically synthesized counterpart of natural antibiotic (+) - erogorgiane extracted from marine coral Pseudopterogorgia elisabethae was studied. This substance has been shown to have bactericidal effect against Mycobacterium smegmatis culture in both logarithmic and stationary growth phases. At the same time, gram negative Escherichia coli is resistant to this compound. The concentration-dependent inhibition of M. smegmatis biofilm formation under sublethal antibiotic action has been observed. The effect of the test compound on the cell surface structure was detected with atomic force microscopy. The attempts to obtain antibiotic resistant mutants on agar media with high antibiotic concentrations failed.

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How to Cite
Нестерова/Nesterova Л. Ю., Ткаченко/Tkachenko А. Г., & Писцова/Pistsova О. Н. (2018). STUDY OF THE (+)-EROGORGIANE ANTIMICROBIAL ACTION MECHANISMS. Bulletin of Perm University. Biology, (4), 351–355. Retrieved from https://press.psu.ru/index.php/bio/article/view/1772
Issue
No. 4 (2016): Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology
Section
Микробиология

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Author Biographies

Лариса/Larisa Юрьевна/Yurievna Нестерова/Nesterova, Institute of Ecology and Genetics of Microorganism UB RAS

Candidate of biology, senior scientist of the laboratory of microorganisms adaptation

Александр/Alexander Георгиевич/Georgievich Ткаченко/Tkachenko, Institute of Ecology and Genetics of Microorganism UB RAS; Perm State University

Head of the laboratory of microorganisms adaptation;Professor, Department of Microbiology and immunology

Ольга/Olga Николаевна/Nikolaevna Писцова/Pistsova, Perm State University

Engineer of microscopy's office Rhodococcus-centre

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_______________________________________________________

Aguayo S., Bozec L. Mechanics of bacterial cells and initial surface colonization. Advances in Experimental Medicine and Biology. V. 915 (2016): pp. 245-260.

Arai M., Niikawa H., Kobayashi M. Marine-derived fungal sesterterpenes, ophiobolins, inhibit biofilm formation of Mycobacterium species. Journal of Natural Medicines. V. 67 No. 2 (2013): pp. 271-275.

De Souza M.V.N. Marine natural products against tuberculosis. The Scientific World Journal. V. 21 No. 6 (2006): pp. 847-861.

Kern W.V., Oethinger M., Jellen-Ritter A., Levy S.V. Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli. Antimicrobial Agents and Chemotherapy. V. 44 No. 4 (2000): pp. 814-820.

Leisner J.J., Jorgensen N.O., Middelboe M. Prédation and selection for antibiotic resistance in natural environments. Evolutionary Applications Journal. V. 9 No. 3 (2016): pp. 427-434.

McMurry L.M., McDermott P.F., LevyS.B. Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan. Antimicrobial Agents and Chemotherapy. V. 43 No. 3 (1999): pp. 711-713.

Migliori G.B., Sotgiu G., Gandhi N.R., Falzon D., DeRiemer К. Drug resistance beyond extensively drug-resistant tuberculosis: individual patient data meta-analysis. European Respiratory Journal. V. 42 No. 1 (2013): pp. 169-179.

Sharma I.M., Petchiappan A., Chatterji D. Quorum sensing and biofilm formation in mycobacteria: role of c-di-GMP and methods to study this second messenger. International Union of Biochemistry and Molecular Biology Life. V. 66 No. 12 (2014): pp. 823-834.

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