РОЛЬ ОТДЕЛЬНЫХ СУБПОПУЛЯЦИЙ CD4+ Т-ЛИМФОЦИТОВ В ПАТОГЕНЕЗЕ ВИЧ-ИНФЕКЦИИ

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Published: Dec 8, 2020

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Евгения Владимировна Сайдакова
ФГБОУВО «Пермский государственный национальный исследовательский университет»
http://orcid.org/0000-0002-4342-5362

Abstract

Пул CD4+ Т-лимфоцитов состоит из клеток различной степени зрелости. Наивные CD4+ Т-лимфоциты, стволовые CD4+ Т-клетки памяти, CD4+ Т-лимфоциты центральной и эффекторной памяти выполняют различные функции в поддержании гомеостаза иммунной системы. Несмотря на фенотипические различия, клетки каждой из этих субпопуляций могут быть инфицированы ВИЧ. При этом особенности CD4+ Т-лимфоцитов разной степени зрелости определяют роль этих клеток в патогенезе ВИЧ-инфекции. По изменению субпопуляционного состава периферических CD4+ Т-лимфоцитов ВИЧ-инфицированных больных можно судить о степени пораженности иммунной системы, а также делать прогнозы эффективности ее восстановления при назначении высокоактивной антиретровирусной терапии. В статье систематизированы основные события, происходящие с CD4+ Т-клетками различной степени зрелости в условиях неконтролируемого течения ВИЧ-инфекции и на фоне антиретровирусной терапии.

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How to Cite
Сайдакова, Е. В. (2020). РОЛЬ ОТДЕЛЬНЫХ СУБПОПУЛЯЦИЙ CD4+ Т-ЛИМФОЦИТОВ В ПАТОГЕНЕЗЕ ВИЧ-ИНФЕКЦИИ. Bulletin of Perm University. Biology, (3), 236–246. Retrieved from https://press.psu.ru/index.php/bio/article/view/3944
Issue
No. 3 (2020): Вестник Пермского университета. Серия Биология. №3. 2020
Section
Иммунология

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Author Biography

Евгения Владимировна Сайдакова, ФГБОУВО «Пермский государственный национальный исследовательский университет»

Кандидат биологических наук, доцент кафедры микробиологии и иммунологии

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