THE ROLE OF PLACENTAL PROTEINS IN THE REGULATION OF INTERLEUKIN-2 PRODUCTION BY NAIVE T-CELLS AND MEMORY T-CELLS

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Published: Oct 27, 2018
Keywords:
human chorionic gonadotropin (hcg) trophoblastic beta-1-glycoprotein (tbg) alpha-fetoprotein pregnancy immune tolerance memory t cells il-2

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Светлана/Svetlana Анатольевна/Anatol'evna Заморина/Zamorina
Institute of Ecology and Genetics of Microorganism UB RAS; Perm State University
Лариса/Larisa Сергеевна/Sergeevna Литвинова/Litvinova
Immanuel Kant Baltic Federal University
Кристина/Kristina Алексеевна/Alekseevna Юрова/Yurova
Immanuel Kant Baltic Federal University
Наталия/Natalia Александровна/Aleksandrovna Дунец/Dunets
Immanuel Kant Baltic Federal University
Ольга/Ol'ga Геннадьевна/Gennad'evna Хазиахматова/Khaziakhmatova
Immanuel Kant Baltic Federal University
Валерия/Valeriya Павловна/Pavlovna Тимганова/Timganova
Institute of Ecology and Genetics of Microorganism UB RAS
Мария/Maria Станиславовна/Stanislavovna Бочкова/Bochkova
Institute of Ecology and Genetics of Microorganism UB RAS
Павел/Pavel Викторович/Viktorovich Храмцов/Khramtsov
Perm State University
Михаил/Mikhail Борисович/Borisovich Раев/Rayev
Institute of Ecology and Genetics of Microorganism UB RAS; Perm State University

Abstract

The effect of physiological concentrations of placental proteins - trophoblastic beta1-glycoprotein (PSG), human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) on the production of interleukin-2 (IL-2) by isolated CD45RA+ and CD45RO+ - cells in an in vitro model has been studied. It was found that at the level of naive T memory cells (CD45RA+) stimulating effect on the production of IL-2 was provided by hCG (10 and 100 IU/ml), and AFP (100 U ml), but not by PSG. Regarding primed memory T cells (CD45RO+), the stimulatory effect showed hCG (10 and 100 IU/ml), and PSG (1 and10 ug/ml), but not AFP. Thus, placental proteins have primarily a stimulating effect on the production of IL-2 memory T-cells.

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How to Cite
Заморина/Zamorina С. А., Литвинова/Litvinova Л. С., Юрова/Yurova К. А., Дунец/Dunets Н. А., Хазиахматова/Khaziakhmatova О. Г., Тимганова/Timganova В. П., Бочкова/Bochkova М. С., Храмцов/Khramtsov П. В., & Раев/Rayev М. Б. (2018). THE ROLE OF PLACENTAL PROTEINS IN THE REGULATION OF INTERLEUKIN-2 PRODUCTION BY NAIVE T-CELLS AND MEMORY T-CELLS. Bulletin of Perm University. Biology, (1), 104–111. Retrieved from https://press.psu.ru/index.php/bio/article/view/1843
Issue
No. 1 (2017): Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology
Section
Клиническая лабораторная диагностика

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Author Biographies

Светлана/Svetlana Анатольевна/Anatol'evna Заморина/Zamorina, Institute of Ecology and Genetics of Microorganism UB RAS; Perm State University

Doctor of biology, professor, senior researcher of laboratory of ecological immunology;Associate professor of the Department of microbiology and immunology

Лариса/Larisa Сергеевна/Sergeevna Литвинова/Litvinova, Immanuel Kant Baltic Federal University

Doctor of medicine, Head of laboratory of immunology and cellular biotechnology

Кристина/Kristina Алексеевна/Alekseevna Юрова/Yurova, Immanuel Kant Baltic Federal University

Candidate of biology, Junior researcher of the laboratory of immunology and cellular biotechnology

Наталия/Natalia Александровна/Aleksandrovna Дунец/Dunets, Immanuel Kant Baltic Federal University

Candidate of biology, Junior researcher of the laboratory of immunology and cellular biotechnology

Ольга/Ol'ga Геннадьевна/Gennad'evna Хазиахматова/Khaziakhmatova, Immanuel Kant Baltic Federal University

Candidate of biology, Junior researcher of the laboratory of immunology and cellular biotechnology

Валерия/Valeriya Павловна/Pavlovna Тимганова/Timganova, Institute of Ecology and Genetics of Microorganism UB RAS

Candidate of biology, Junior researcher of the laboratory of ecological immunology

Мария/Maria Станиславовна/Stanislavovna Бочкова/Bochkova, Institute of Ecology and Genetics of Microorganism UB RAS

Candidate of biology, researcher of the laboratory of ecological immunology

Павел/Pavel Викторович/Viktorovich Храмцов/Khramtsov, Perm State University

Candidate of biology, assistant of the Department of microbiology and immunology

Михаил/Mikhail Борисович/Borisovich Раев/Rayev, Institute of Ecology and Genetics of Microorganism UB RAS; Perm State University

Doctor of biology, leading researcher of the laboratory of ecological immunology;Professor of the Department of microbiology and immunology

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