ASSESSMENT OF ACUTE TOXICITY AND CUMULATIVE PROPERTIES OF NANODISPERSE OXIDE OF COBALT AT INHALATION AND ORAL RECEIPT

Abstract

The article presents the results of research and assessment of acute toxicity and cumulative properties of nanosized oxide of cobalt at inhalation and oral receipt. Nanoparticles of oxide of cobalt are widely applied in electroinstrument making, chemical and metallurgical industry. It is important to systematize and specify data on physical and toxicological parameters of nanodimensional metal-containing particles at various ways of receipt to an organism. By results of own pilot studies it is established that the studied sample of nanodisperse oxide of cobalt is nanomaterial (the size of particles is equal in diameter to 41,277,9 nanometers, is 6,8 times less than particles of microdisperse analog (0,281-4,91mkm)) that can increase its reactionary ability. Doesn't possess acute inhalation and oral toxicity. At inhalation receipt possesses bigger penetration in a liver (concentration has made 0,168 mg/g) that is in 2,21 higher in comparison with microdisperse analog (0,076 mg/g), bigger penetration in a brain (0,046 mg/g) that is in 20,84 higher in comparison with microdisperse analog (0,022 mg/g). Possesses more expressed material cumulation in comparison with a cumulation of microdisperse analog: in a brain (concentration has made 0,733 mg/kg), what is 2,07 times more, in a liver (76,94 mg/kg) - by 27,4 times and in kidneys (141,608 mg/kg) - by 155,3 times.