MODIFYING EFFECT OF GRAPE SKIN AND RED WINE EXTRACTS ON ESCHERICHIA COLI SUSCEPTIBILITY TO VARIOUS ANTIBIOTICS

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Published: Oct 25, 2018
Keywords:
plant extracts polyphenols antioxidant genes antibiotics e. coli

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Ксения/Kseniya Викторовна/Viktorovna Безматерных/Bezmaternykh
Institute of Ecology and Genetics of Microorganism UB RAS
Галина/Galina Васильевна/Vasil'evna Смирнова/Smirnova
Institute of Ecology and Genetics of Microorganism UB RAS
Олег/Oleg Николаевич/Nikolaevich Октябрьский/Oktyabrsky
Institute of Ecology and Genetics of Microorganism UB RAS; Perm National Research Polytechnic University

Abstract

Extracts from red wine and grape skin contain a significant amount of polyphenols, including quercetin and resveratrol, and possess high antiradical and chelating ability. Addition of these extracts into E. coli culture causes a 30% inhibition of the growth rate, an induction of antioxidant genes katG and sodA and a rise in H2O2 resistance. Pretreatment of E. coli with the extracts attenuates bactericidal activity of ciprofloxacin and cefotaxim and, in contrast, augments E. coli susceptibility to kanamycin and streptomycin. The extracts may exert their action by influence on the growth rate, redox state of cells and expression of antioxidant genes. In the case of ciprofloxacin, pretreatment with the extracts can decrease DNA damage and the level of the SOS response. The modulating effect of extracts should be taken into consideration in antibiotic therapy.

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How to Cite
Безматерных/Bezmaternykh К. В., Смирнова/Smirnova Г. В., & Октябрьский/Oktyabrsky О. Н. (2018). MODIFYING EFFECT OF GRAPE SKIN AND RED WINE EXTRACTS ON ESCHERICHIA COLI SUSCEPTIBILITY TO VARIOUS ANTIBIOTICS. Bulletin of Perm University. Biology, (4), 322–329. Retrieved from https://press.psu.ru/index.php/bio/article/view/1768
Issue
No. 4 (2016): Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology
Section
Микробиология

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Author Biographies

Ксения/Kseniya Викторовна/Viktorovna Безматерных/Bezmaternykh, Institute of Ecology and Genetics of Microorganism UB RAS

Engineer of laboratory of physiology and genetics of microorganisms

Галина/Galina Васильевна/Vasil'evna Смирнова/Smirnova, Institute of Ecology and Genetics of Microorganism UB RAS

Doctor of biology, leading researcher of laboratory of physiology and genetics of microorganisms

Олег/Oleg Николаевич/Nikolaevich Октябрьский/Oktyabrsky, Institute of Ecology and Genetics of Microorganism UB RAS; Perm National Research Polytechnic University

Professor, director of laboratory of physiology and genetics of microorganisms;Professor of the Department of Chemistry and Biotechnology

References

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Drlica K., Malik M., Kerns R.J. et al. Quinolone-mediated bacterial death. Antimicrob. Agents Chemother. V. 52 (2008): pp. 385-392.

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Hwang D., Lim Y.H. Resveratrol antibacterial activity against Escherichia coli is mediated by Z-ring formation inhibition via suppression of FtsZ expression. Sci. Rep. V. 5 (2015): pp. 10029.

Kim H-J., Chen F., Wang X. et al. Evalution of antioxidant activity of Vetiver (Vetiveria zizanioides L.) oil and identification of its antioxidant constituents. J. Agric. Food Chem. V. 53. (2005): pp. 7691-7695.

Marathe S.A., Kumar R., Ajitkumar P. et al. Curcumin reduces the antimicrobial activity of ciprofloxacin against Salmonella typhimurium and Salmonella typhi. J. Antimicrob. Chemother. V. 68 (2013): pp. 139-152.

Miller J.H. Experiments in molecular genetics. New York: Cold Spring Harbor Laboratory Press. 1972.

Obeidat M., Shatnawi M., Al dmoor H. et al. Antimicrobial activity of crude extracts of some plant leaves. Res. J. Microbiol. V. 7 (2012): pp. 59-67.

Perron N.R., Brumaghim J.L. A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochem. Biophys. V. 53 (2009): pp. 75-100.

Piddock L.J.V., Wise R. Induction of the SOS response in Escherichia coli by 4-quinolone antimicrobial agents. FEMS Microbiol. Lett. V. 41 (1987): pp. 289-294.

Rice-Evans C.A., Miller N.J., Bolwell P.G. et al. The relative antioxidant actuvities of plant-derived polyphenolic flavonoids. Free Radic. Res. V. 22 (1995): pp. 375-383.

Samoilova Z., Smirnova G., Muzyka N. et al. Medicinal plant extracts variously modulate susceptibility of Escherichia coli to different antibiotics. Microb. Res. V. 169 (2014): pp. 307-317.

Scalbert A. Antimicrobial properties of tannins. Phytochemistry. V. 30 (1991): pp. 3875-3883.

Shyur L-F., Tsung J-H., Chen J-H. et al. Antioxidant properties of extracts from medicinal plants popularly used in Taiwan. Lnter. J. Appl. Sci. Eng. Technol. V. 3 (2005): pp. 195-202.

Smirnova G.V., Samoylova Z.Y., Muzyka N.G. et al. Influence of polyphenols on Escherichia coli resistance to oxidative stress. Free Radic. Biol. Med. V. 46 (2009): pp. 759-768.

Smirnova G., Samoilova Z., Muzyka N. et al. Influence of plant polyphenols and medicinal plant extracts on antibiotic susceptibility of Escherichia coli. J. Appl. Microbiol. V. 113 (2012): pp. 192-199.

Smith A.H., Imlay J.A., Mackie R.I. Increasing the oxidative stress response allows Escherichia coli to overcome inhibitory effects of condensed tannins. Appl. Environ. Microbiol. V. 69 (2003): pp. 3406-3411.

Subramanian M., Goswami M., Chakraborty S. Res-veratrol induced inhibition of Escherichia coli proceeds via membrane oxidation and independent of diffusible reactive oxygen species generation. Redox biology. V. 2 (2014): pp. 865-872.

Tang S.Y., Halliwell B. Medicinal plants and antioxidants: What do we learn from cell culture and Caenorhabditis elegans studies? Biochem. Biophys. Res. Commun. V. 394 (2010): pp. 1-5.

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Wu L-C., Hsu H-W., Chen Y-C. et al. Antioxidant and antiproliferative activities of red pitaya. Food Chem. V. 95 (2006): pp. 319-327.

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