Association of iron ion metabolism and the quantitative ratio of different populations of peripheral blood leukocytes during pregnancy

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Published: Oct 30, 2025
DOI: https://doi.org/10.17072/1994-9952-2025-3-305-312
Keywords:
ferritin iron ion peripheral blood leukocytes pregnancy

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Ekaterina G. Orlova
Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the RAS, Perm, Russia
Olga L. Gorbunova
Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the RAS, Perm, Russia
Nina V. Karimova
Centralized Clinical Diagnostic Laboratory, Perm, Russia

Abstract

The study examined the iron ion exchange parameters and the quantitative composition of peripheral blood leukocytes and red blood cells in healthy women during the first trimester of normal pregnancy. It was found that the serum ferritin concentration has a direct relationship with the serum iron concentration, but an inverse relationship with the percentage and absolute number of neutrophils and monocytes, as well as the average hemoglobin concentration in red blood cells. A positive correlation was found between serum iron levels and the total number of white blood cells. The obtained results expand our understanding of the relationship between iron ion metabolism indicators and the quantitative characteristics of peripheral blood leukocytes during physiological pregnancy.

Article Details

How to Cite
Orlova Е. Г., Gorbunova О. Л., & Karimova Н. В. (2025). Association of iron ion metabolism and the quantitative ratio of different populations of peripheral blood leukocytes during pregnancy. Bulletin of Perm University. Biology, (3), 305–312. https://doi.org/10.17072/1994-9952-2025-3-305-312
Issue
No. 3 (2025): Bulletin of Perm University. BIOLOGY
Section
Иммунология

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Author Biographies

Ekaterina G. Orlova, Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the RAS, Perm, Russia

doctor of biology, leading researcher of laboratory of immunoregulation

Olga L. Gorbunova, Perm Federal Research Center, Institute of Ecology and Genetics of Microorganisms, Ural Branch of the RAS, Perm, Russia

candidate of biology, researcher of laboratory of immunoregulation

Nina V. Karimova, Centralized Clinical Diagnostic Laboratory, Perm, Russia

Head of the Centralized Clinical and Diagnostic Laboratory
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References

Бобров С.А., Репина М.А., Клиценко О.А. Сывороточный ферритин как фактор прогноза развития железодефицитной анемии у беременных женщин // Журнал акушерства и женских болезней. 2011. Т. 60, № 3. С. 49–55. EDN: OFSQIX.

Матюшичев В.Б., Шамратова В.Г. Взаимосвязи показателей эритроцитов и лейкоцитов крови при железодефицитной анемии // Biological Communications. 2005. № 1. С. 93–97. EDN: RTSYVF.

Орлова Е.Г. и др. Метаболические особенности гранулоцитов периферической крови при физиоло-гической беременности // Вестник Уральской медицинской академической науки. 2024. Том 21, № 3. С. 233–241. EDN: FYWKOM.

Сидорко Т.Н., Калмаханов С.Б. Анемия беременных и ферритин: природа ничего не создает напрасно (Обзор литературы) // Вестник КазНМУ. 2020. № 2. С. 31–36. EDN: MIQQOD.

Терещенко С.Ю., Пахмутова О.А. К вопросу о нормативных значениях уровня сывороточного фер-ритина для диагностики железодефицитного состояния // Гематология и трансфузиология. 2012. Т. 57, № S3. С. 140. EDN: QOAGYK.

Циркин В.И. и др. Роль нейтрофилов в физиологическом течении беременности и родов и некото-рых акушерских осложнениях // Вестник Уральской академической науки. 2015. № 4(55). С. 75–86. EDN: VKFDNH.

Ширшев С.В. Иммунология материнско-фетальных взаимодействий. Екатеринбург, 2009. 582 с.

Ширшев С.В., Куклина Е.М., Баженова А.В. Влияние прогестерона на фагоцитарную и окисли-тельную активность моноцитов и нейтрофилов // Вестник Пермского университета. 2008. Вып. 9(25), Биология. С. 87–90.

Юрасов В.В. и др. Изучение связи концентрации железа с показателями ферритина и трансферрина в сыворотке крови // Молекулярная медицина. 2023. Т. 21, № 1. C. 37–42. DOI: 10.29296/24999490-2023-01-05

Arosio P., Elia L., Poli M. Ferritin, cellular iron storage and regulation // IUBMB Life 2017. Vol. 69. P. 414-422. DOI: 10.1002/iub.1621.

Frost J.N. et al. Plasma iron controls neutrophil production and function // Sci. Adv. 2022. Vol. 8(40). Art. eabq5384. DOI: 10.1126/SCIADV.ABQ5384.

Kuźmicka W. et al. Iron excess affects release of neutrophil extracellular traps and reactive oxygen spe-cies but does not influence other functions of neutrophils // Immunol. Cell. Biol. 2022. Vol. 100(2). P. 87–100. DOI: 10.1111/IMCB.12509.

Ozel A., Davutoglu E.A., Yurtkal A. How do platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio change in women with preterm premature rupture of membranes, and threaten preterm labour? // Journal of Obstetrics and Gynaecology. 2020. Vol. 40(2). P. 195–199. DOI: 10.1080/01443615.2019.1621807.

Sanci M., Töz E., Ince O. Reference values for maternal total and differential leukocytes counts in dif-ferent trimesters of pregnancy and the initial postpartum period in western Turkey // Journal of Obstetrics and Gynaecology. 2017. Vol. 37(5). P. 571–575. DOI: 10.1080/01443615.2016.1268575.