Analysis of associations of the level of personal anxiety with allelic variations of metabolic genes

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Published: Oct 30, 2025
DOI: https://doi.org/10.17072/1994-9952-2025-3-298-304
Keywords:
anxiety mental health metabolic genes psychogenetics

Main Article Content

Yuliya S. Novokovich
Center for Genomic Technologies «Cerbalab», St. Petersburg, Russia
Oleg S. Glotov
Center for Genomic Technologies «Cerbalab», St. Petersburg, Russia
Mikhail V. Aseev
Center for Genomic Technologies «Cerbalab», St. Petersburg, Russia
Alexey V. Kusakin
Center for Genomic Technologies «Cerbalab», St. Petersburg, Russia
Dmtriy E. Polev
Center for Genomic Technologies «Cerbalab», St. Petersburg, Russia
Andrey S. Glotov
D.O. Ott Research Institute for Obstetrics, Gynaecology and Reproductology, St. Petersburg, Russia

Abstract

The study is devoted to the identification of genetic markers associated with increased personal anxiety among 119 mentally healthy people, mainly of Russian nationality, living in the European part of Russia. The level of personal anxiety was determined using the Spielberger-Khanin questionnaire and self-questioning. Gene variants COMT rs4633, rs4680, APOE rs429358, rs7412, CBS rs234706, rs4920037, MTHFR rs1801131, rs1801133, NOS3 rs1800779, and VDR rs2228570 were determined using PCR-RDRF analysis and Real-Time PCR. Statistical processing of the results was carried out using a two-way accurate Fisher test, with a threshold significance level of p value <0.05. An association with increased anxiety was found for APOE rs7412 C/T (p=0.02), APOE e2/e3 (p=0.04), CBS rs4920037 A/A (p=0.019), NOS3 rs1800779A/A (p=0.008), VDR rs2228570 G/G (p=0.034) with moderate and low anxiety are associated: NOS3 rs1800779A/G (p=0.01), APOE e3/e4 (p=0.035).

Article Details

How to Cite
Novokovich Ю. С., Glotov О. С. ., Aseev М. В. ., Kusakin А. В. ., Polev Д. Е. ., & Glotov А. С. . (2025). Analysis of associations of the level of personal anxiety with allelic variations of metabolic genes. Bulletin of Perm University. Biology, (3), 298–304. https://doi.org/10.17072/1994-9952-2025-3-298-304
Issue
No. 3 (2025): Bulletin of Perm University. BIOLOGY
Section
Генетика

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Author Biographies

Yuliya S. Novokovich , Center for Genomic Technologies «Cerbalab», St. Petersburg, Russia

Commercial Director

Oleg S. Glotov , Center for Genomic Technologies «Cerbalab», St. Petersburg, Russia

Doctor of Biology, Director of Science

Mikhail V. Aseev , Center for Genomic Technologies «Cerbalab», St. Petersburg, Russia

Candidate of Biological Sciences

Alexey V. Kusakin , Center for Genomic Technologies «Cerbalab», St. Petersburg, Russia

Bioinformatics

Dmtriy E. Polev , Center for Genomic Technologies «Cerbalab», St. Petersburg, Russia

Candidate of Biological Sciences, Chief Biologist

Andrey S. Glotov , D.O. Ott Research Institute for Obstetrics, Gynaecology and Reproductology, St. Petersburg, Russia

Doctor of Biology, Head of the V.S. Baranov Department of Genomic Medicine
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