REDUCING STAPHYLOCOCCUS EPIDERMIDIS COLONIZATION OF POLYDIMETHYLSILOXANE
Keywords:
biofilms, staphylococcus epidermidis, polydimethylsiloxane, modification, ion-beam treatmentAbstract
Modification of polydimethylsiloxane (PDMS) surface by a combined physical and chemical method has been carried out. The method consists in ion-beam treatment followed by grafting of acrylic acid and interaction with chemicals. As a result, amino groups and coordination compounds of the zinc(II) ion have been assumed to appear on the polymer surface. The biofilms of Staphylococcus epidermidis clinical strains adhered to the initial and modified surfaces has been studied by scanning electron microscopy. In this paper microbial contamination of surface modified silicone rubber was shown to be significantly reduced. This modification technique can be suggested for antibacterial treatment of medical devices made of silicon rubber.References
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Kondyurin A., BilekM. Ion Beam Treatment of Polymers: Application Aspects from Medicine to Space. Elsevier, 2015. P. 185-215.
Mekewi M. et al. Imparting permanent antimicrobial activity onto viscose and acrylic fibers // International Journal of Biological Macromole-cules. 2012.Vol. 50. P. 1055-1062.
Otto M. Staphylococcal biofilms // Current Topics in Microbiology and Immunology. 2008. Vol. 322. P. 207-208.
Padmavathy N., Vijayaraghavan R. Enhanced bioac-tivity of ZnO nanoparticles—an antimicrobial study // Science and Technology of Advanced Materials. 2008. Vol. 9. P. 035004(l)-035004(7).
Pasqueta J. et al. The contribution of zinc ions to the antimicrobial activity of zinc oxide // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2014. Vol. 457. P. 263-274.
Pavlukhina S., Sukhishvili S. Polymer assemblies for controlled delivery of bioactive molecules from surfaces // Advanced Drug Delivery Reviews. 2011. Vol. 63. P. 822-836.
Zhang L. et al. Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli II Journal Nanoparti-cle Research. 2010. Vol. 12. P. 1625-1636.
References
Bozhkova S. A. et. al. [Ability to formation of biofilms of S. aureus u S. epidermidis clinical strains - the main causative agents of implant-associated infections] Klinicheskaya microbi-ologiya i antimicrobnaya khimioterapiya. 2014. V. 16. Is. 2. P. 149-156. (In Russ.)
Busscher H. .J., et al. Biomaterial-associated infection: locating the finish line in the race for the surface. Science Translational Medicine. 2012, V. 4, pp. 153rvl0.
Chu, P.K. et al. Plasma-surface modification of biomaterials. Material Science Engineering: R: reports. 2002, V 36, Is. 5-6, pp. 143-206.
Donlan R.M., Biofilms and device-associated infections. Emerging. Infectious Diseases. 2001, Is. 2, V. 7, pp. 277-281.
Ektessabi A.M., Sano T. Sputtering and thermal effect during ion microbeam patterning of polymeric films. Review of Scientific Instruments. 2000, V. 71, Is. 2, pp. 1012-1015.
Jiang X., Pace J.L. Microbial Biofilms. Biofilms, Infection and Antimicrobial Therapy; Pace J.L., Rupp M.,Finch R.G., eds. Taylor & Francis Group: Boca Raton,FL, USA. 2006, pp. 3-19.
Katsikogianni M., Missirlis Y.F. Concise review of mechanisms of bacterial adhesion to biomaterials and of techniques used in estimating bacteria-material interactions. European Cells and Materials. 2004, V. 8. pp. 37-57.
Kondyurin A., Bilek M. Ion Beam Treatment of Polymers: Application Aspects from Medicine to Space. Elsevier, 2015, pp. 185-215.
Mekewi M. et al. Imparting permanent antimicrobial activity onto viscose and acrylic fibers. International Journal of Biological Macromole-cules. 2012,V. 50, pp. 1055-1062.
Otto M. Staphylococcal biofilms. Current Topics in Microbiology and Immunology. 2008, V. 322, pp. 207-208.
Padmavathy N., Vijayaraghavan R. Enhanced bioac-tivity of ZnO nanoparticles—an antimicrobial study. Science and Technology of Advanced Materials. 2008, V. 9, pp. 035004(l)-035004(7).
Pasqueta J. et al. The contribution of zinc ions to the antimicrobial activity of zinc oxide. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2014, V. 457, pp. 263-274.
Pavlukhina S, Sukhishvili S. Polymer assemblies for controlled delivery of bioactive molecules from surfaces. Advanced Drug Delivery Reviews. 2011, V. 63, pp. 822-836.
Zhang L. et al. Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli. Journal Nanoparti-cle Research. 2010, V. 12, pp. 1625-1636.
