SEMAPHORIN SEMA4D IN THE REGULATION OF TFH-LIKE CELLS
Keywords:
sema4d, follicular helper t cells, b lymphocyte differentiationAbstract
The role of endogenous semaphorin Sema4D in the control of circulating follicular T helper cells (CD4 CXCR5 Т lymphocytes) has been studied. The involving of Sema4D in functional molecule PD-1 expression increasing, as well as in T-dependent B lymphocyte differentiation in T-/B-coculture in response to polyclonal T lymphocyte activation was shown. The data demonstrate a possible new mechanism of Sema4D-dependent regulation of the humoral immune response, implying the direct semaphorin participation in B-lymphocyte differentiation, supported by follicular helper T cells.References
Feng J. et al. High frequency of CD4+CXCR5+TFH cells in patients with immune-active chronic hepatitis В // PLoS One. 2011. Vol. 6, № 7. P. 1-9.
Good-Jacobson K.L. et al. PD-1 regulates germinal center В cell survival and the formation and affinity of long-lived plasma cells // Nat. Immunol. 2010. Vol. 11, № 6. P. 535-542.
Jourdan M. et al. Characterization of a transitional preplasmablast population in the process of human В cell to plasma cell differentiation //
J. Immunol. 2011. Vol. 187, № 8. P. 3931-3941.
Kumanogoh A. et al. Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating В cell signaling // Immunity. 2000. Vol. 13, № 5. P. 621-631.
Kumanogoh A. et al. Requirement for the lymphocyte semaphorin, CD 100, in the induction of antigen-specific T cells and the maturation of dendritic cells // J. Immunol. 2002. Vol. 169, № 3. P. 1175-1181.
Morita R. et al. Human blood CXCR5+CD4+T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion //Immunity. 2011. Vol. 34, № 1. P. 108-121.
Oi H. T follicular helper cells in space-time // Nature. 2016. Vol. 16. P. 612-625.
T follicular helper cells. Preface / eds. M. Espeli, Ml. Linterman // Methods in Molecular Biology. 2015. Vol. 1291. P. 209-226.
WangX. et al. Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses // Blood. 2001. Vol. 97, № 11. P. 3498-3504.
Zhang Y. et al. Sema 4D/CD100-plexin B is a multifunctional counter-receptor // Cell. Mol. Immunol. 2013. Vol. 10, №2. P. 97-98.
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Espeli M., Linterman Ml. (eds.) T follicular helper cells. Preface. Methods in Molecular Biology. V. 1291. (2015): pp. 209-226.
Feng J., Lu L., Hua C., Qin L., Zhao P., Wang J., Wang Y., Li W., Shi X., Jiang Y. High frequency of CD4+CXCR5+TFH cells in patients with immune-active chronic hepatitis B. PLoS One. V. 6. N. 7 (2011): pp. 1-9.
Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, Shlomchik MJ. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol. V. 11. N. 6 (2010): pp. 535-542.
Jourdan M., Caraux A., Caron G., Robert N, Fiol G, Rème T, Bolloré K, Vendrell JP, Le Gallou S, Mourcin F, De Vos J, Kassambara A, Duperray C, Hose D, Fest T, Tarte K, Klein B. Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation. J. Immunol. V. 187. N. 8 (2011): pp. 3931-3941.
Kumanogoh A., Suzuki K., Ch'ng E., Watanabe C., Marukawa S., Takegahara N., Ishida I., Sato T., Habu S., Yoshida K., Shi W., Kikutani H. Requirement for the lymphocyte semaphorin, CD 100, in the induction of antigen-specific T cells and the maturation of dendritic cells. J. Immunol. V. 169. N. 3 (2002): pp. 1175-1181.
Kumanogoh A., Watanabe C., Lee I., Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H. Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating В cell signaling. Immunity. V. 13. N. 5 (2000): pp. 621-631.
Morita R., Schmitt N., Bentebibel S., Ranganathan R., Bourdery L., Zurawski G., Foucat E., Dullaers M., Oh S., Sabzghabaei N., Lavecchio E., Punaro M., Pascual V., Banchereau J., Ueno H. Human blood CXCR5+CD4+T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. V. 34. N. 1 (2011): pp. 108-121.
Oi H. T follicular helper cells in space-time. Nature. V. 16 (2016): pp. 612-625.
Wang X., Kumanogoh A., Watanabe C., Shi W., Yoshida K., Kikutani H. Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses. Blood. V. 97. N. 11 (2001): pp. 3498-3504.
Zhang Y., Liu В., Ma Y., Jin B. Sema 4D/CD100-plexin В is a multifunctional counter-receptor Cell. Mol. Immunol. 2013. V. 10. N. 2 (2013): pp. 97-98.
