Influence of AGT and AGTR1 Gene Polymorphisms on the Development of Arterial Hypertension and Physical Fitness Level in Martial Artists from the city of Perm
DOI:
https://doi.org/10.17072/1994-9952-2026-2-191-199Keywords:
AGT and AGTR1 gene polymorphism, arterial hypertension, martial artists, physical fitness levelAbstract
To optimize training, it is crucial to understand martial artists' predisposition to developing physical qualities, as well as their susceptibility to cardiovascular diseases such as hypertension. The aim of this study was to investigate the association of AGT and AGTR1 gene polymorphisms with the development of hypertension and physical fitness level (PFL) in martial artists from the city of Perm. The study sample included 430 individuals, including 312 martial artists and 118 schoolchildren who do not participate in sports (a control group). To investigate associations between AGT and AGTR1 allelic forms and hypertension, the subjects were divided into two groups: Group I, including subjects with normal blood pressure, and Group II, which included subjects with hypertension. qPCR was performed on DNA samples from subjects aged 10 to 16 years.The Pearson chi-square test (χ2) revealed a significant association between the AGT T/T genotype, the AGTR1 C/C genotype, and the development of arterial hypertension (χ2 = 102.4). An analysis of the relationship between martial arts and physical fitness level (PFL) revealed a tendency toward high levels of physical fitness across all disciplines (χ2 = 34.340). Spearman's rank correlation analysis revealed a positive association between the AGT T/T genotype (rs = 0.374) and the AGTR1 C/C genotype (rs = 0.390) with the level of physical condition in the subjects. Based on genetic analysis data obtained through rapid testing, individualized training programs at sports schools can be developed considering the specific athlete's genotype and physical fitness characteristics.References
Список источников
1. Александров А.А. Повышенное артериальное давление в детском и подростковом возрасте (ювенильная артериальная гипертония) // РМЖ, 1997. № 9. С. 559–565.
2. Александров А.А. и др. Диагностика, лечение и профилактика артериальной гипертензии у де-тей и подростков. Российские рекомендации (второй пересмотр) // Кардиоваскулярная терапия и профилактика, 2009. Т. 8, № 4 С. 1–32.
3. Андриянова Е.Ю. Спортивная медицина. М.: Юрайт, 2020. 436 с. EDN: RBBBUI
4. Баранов В.С. Генетический паспорт – основа индивидуальной и предиктивной медицины. СПб.: Изд-во Н-Л, 2009. 528 с.
5. Вострикова А.В., Боронникова С.В., Закиров Р.М. Молекулярно-генетический анализ генов ACTN3 и AMPD1 у дзюдоистов спортивной школы по самбо и дзюдо «Витязь» г. Перми // Бюллетень науки и практики, 2020. № 4. C. 27–35. DOI: 10.33619/2414-2948/53/03. EDN: XDBPUZ
6. Голованова Н.Э., Астратенкова И.В., Лукьянова И.Ю. Полиморфизм генов и профессиональная деятельность как факторы риска развития артериальной гипертензии // Вестник Санкт-Петербургского университета. Медицина. 2023. Т. 18, вып. 1. С. 4–11. DOI: 10.21638/spbu11.2023.101. EDN: DCATWS
7. Иванов С.Ю, Лившиц Н.И. Точность измерения артериального давления по тонам Короткова в сравнении с осциллометрическим методом // Вестник аритмологии, 2005. № 40. С. 55–58. EDN: HSSHYF
8. Калакуток З.Н. Полиморфизм генов ренин-ангиотензин-альдостероновой системы и риск разви-тия эссенциальной гипертонии у адыгов и русских: автореф. дис. … канд. мед. наук. Майкоп, 2002. 24 с.
9. Нгуен Т.Ч., Шкурат Т.П. Исследование ассоциации Т174М и M235T гена ангиотензиногена с ишемической болезнью сердца в ростовской популяции // Эпидемиология. 2010. Т. 11. С. 114–121.
10. Пахомя Н.С., Урясьев О.М., Шаханов А.В. Роль полиморфизмов некоторых генов в реализации артериальной гипертензии // Земский врач. 2014. Т. 24. С. 21–24.
11. Пирогова Е.А., Иващенко Л.Я., Страчко Н.П. Влияние физических упражнений на работоспо-собность и здоровье человека. Киев: Здоровье, 1986. 152 с.
12. Потапов В.Е. и др. Особенности распределения однонуклеотидных полиморфизмов генов, ас-социированных с артериальной гипертензией у больных с хронической болезнью почек // Смолен-ский медицинский альманах. 2015. Т. 1. С. 138. EDN: OTJDHH
13. Хигучи С. и др. Передача сигнала ангиотензина II через рецептор AT1: новые данные о меха-низмах и патофизиологии // Клиническая наука. 2007. Т. 112. С. 417–428.
14. Чедов К.В. Физическая культура. Врачебный контроль и самоконтроль занимающихся физиче-скими упражнениями и спортом [Электронный ресурс]: учебно-методическое пособие. Пермь, ПГНИУ, 2021. URL: https://elis.psu.ru/node/642456?fragment=page-2 (дата обращения: 03.03.2026). EDN: TFCXSS
15. Chaddock R.E. Principles and methods of statistics. Boston, New York [etc.]: Houghton Mifflin. 1925. 471 p.
16. Jones A. et al. Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension // Hypertension. 2003. Vol. 42, № 4. P. 500–506.
17. Kambouris M. et al. Predictive Genomics DNA Profiling for Athletic Performance // Recent Patents on DNA & Gene Sequences, 2012. Vol. 6, № 3. P. 229–239.
18. Nalogowska-Glosnicka K. et al. PIH Study Group. Angiotensin II type 1 receptor gene A1166C pol-ymorphism is as sociated with the increased risk of pregnancy-induced hypertension // Med. Sci. Monit. 2000. Vol. 6, № 3. P. 523–529.
References
1. Aleksandrov A.A. [High blood pressure in childhood and adolescence (juvenile arterial hyperten-sion)]. RMŽ. No. 9 (1997): pp. 559-565. (In Russ.).
2. Aleksandrov A.A., Kislyak O.A., Leont’eva I.V., Rozanov V.B. [Diagnosis, treatment and prevention of arterial hypertension in children and adolescents]. Kardiovaskuljarnaja terapija i profilaktika. V. 8, No. 4 (2009): pp. 1-32. (In Russ.).
3. Andriyanova E.Yu. Sportivnaja medicina [Sports medicine]. Moscow, Jurajt Publ., 2020. 436 p. (In Russ.). EDN: RBBBUI
4. Baranov V.S. Genetičeskij passport - osnova individual’noj i prediktivnoj mediciny [Genetic pass-port is the basis of individual and predictive medicine]. St-Peterburg, N-L Publ., 2009. 528 p. (In Russ.).
5. Vostrikova A.V., Boronnikova S.V., Zakirov R.M. [Molecular genetic analysis of the ACTN3 and AMPD1 genes in judokas of the sports school for sambo and judo “Vityaz” in Perm]. Bjulleten' nauki i praktiki. No. 4 (2020): pp. 27-35. (In Russ.). DOI: 10.33619/2414-2948/53/03. EDN: XDBPUZ
6. Golovanova N.E., Astrahenkova I.V., Luk'yanova I.Yu. [Gene polymorphism and professional activi-ty as risk factors for the development of arterial hypertension]. Vestnik Sankt-Peterburgskogo universi-teta. Medicina. V. 18, iss. 1 (2023): pp. 4-11. (In Russ.). DOI: 10.21638/spbu11.2023.101. EDN: DCATWS
7. Ivanov S.Yu, Livshits N.I. [Accuracy of blood pressure measurement using Korotkov sounds in com-parison with the oscillometric method]. Vestnik aritmologii. No. 40 (2005): pp. 55-58. (In Russ.). EDN: HSSHYF
8. Kalakutok Z.N. Polimorfizm genov renin-angiotenzin-al’dosteronovoj sistemy i risk razvitija essen-cial'noj gipertenzii u adygov i russkich: avtoref. dis. … kand. med. nauk. [Polymorphism of the genes of the renin-angiotensin-aldosterone system and the risk of developing essential hypertension in Adyghe and Russians: Abstract of a PhD thesis]. Maikop, 2002. 24 p. (In Russ.).
9. Nguyen T.Ch., Shkurat T.P. [Study of the association of T174M and M235T of the angiotensinogen gene with coronary heart disease in the Rostov population]. Epidemiologija. V. 11 (2010): pp. 114-121. (In Russ.).
10. Pakhomya N.S., Uryas'ev O.M., Shakhanov A.V. [The role of polymorphisms of some genes in the development of arterial hypertension]. Zemskij vrač. V. 24 (2014): pp. 21-24. (In Russ.). EDN: TAWVST
11. Pirogova E.A., Ivaschenko L.Ya., Strachko N.P. Vlijanie fizičeskich upražnenij na rabotosposob-nost' i zdorov'e čeloveka [The impact of physical exercise on human performance and health]. Kiev, Zdo-rov'e Publ., 1986. 152 p. (In Russ.).
12. Potapov V.E., Logvinov A.K., Zarutskiy S.A. et al. [Features of the distribution of single nucleotide polymorphisms of genes associated with arterial hypertension in patients with chronic kidney disease]. Smolenskij medicinskij al'manach. V. 1 (2015): p. 138. (In Russ.). EDN: OTJDHH
13. Khiguchi S., Okhcu H., Suzuki H., Sairai H., Frank G.D., Eguchi S. [Angiotensin II signaling through the AT1 receptor: new insights into mechanisms and pathophysiology]. Kliničeskaja nauka, V. 112 (2007): pp. 417-428.
14. Chedov K.V. Fizičeskaja kul‘tura. Vračebnyj kontrol' i samokontrol; zanimajuščichsja fizičeskimi upražnenijami i sportom [Medical supervision and self-monitoring of those involved in physical exercise and sports]. Perm, PGNIU, 2021. (In Russ.). Available at: https://elis.psu.ru/node/642456?fragment=page-2 (accessed 03.03.2026). EDN: TFCXSS
15. Chaddock R.E. Principles and methods of statistics. Boston, New York [etc.], Houghton Mifflin. 1925. 471 p.
16. Jones A., Dhamrait S.S., Payne J.R. et al. Genetic variants of angiotensin II receptors and cardiovas-cular risk in hypertension. Hypertension. V. 42, Nо. 4 (2003): pp. 500-506.
17. Kambouris M., Ntalouka F., Ziogas G., Maffulli N. Predictive Genomics DNA Profiling for Athletic Performance. Recent Patents on DNA & Gene Sequences. V. 6, No. 3 (2012): pp. 229-239.
18. Nalogowska-Glosnicka K., Lacka B.I., Zychma M.J. et al. PIH Study Group. Angiotensin II type 1 receptor gene A1166C polymorphism is as sociated with the increased risk of pregnancy-induced hypertension. Med. Sci. Monit. V. 6, Nо. 3 (2000): pp. 523-529.
