FEATURES OF GENETIC AND IMMUNOLOGICAL PARAMETERS IN THE WORKERS OF CONTINUOUS PRODUCTION CYCLE

Authors

  • Олег/Oleg Владимирович/Vladimirovich Долгих/Dolgikh FBSI «FSC for Medical and Preventive Health Risk Management Technologies»; Perm State University; Perm National Research Polytechnic University
  • Александр/Alexandr Владимирович/Vladimirovich Кривцов/Krivtsov FBSI «FSC for Medical and Preventive Health Risk Management Technologies»
  • Ксения/Ksenia Геннадьевна/Gennadiyevna Старкова/Starkova FBSI «FSC for Medical and Preventive Health Risk Management Technologies»
  • Дмитрий/Dmitri Владимирович/Vladimirovich Ланин/Lanin FBSI «FSC for Medical and Preventive Health Risk Management Technologies»; Perm State University
  • Ольга/Olga Алексеевна/Alekseevna Бубнова/Bubnova FBSI «FSC for Medical and Preventive Health Risk Management Technologies»
  • Дина/Dina Гумерова/Gumerovna Дианова/Dianova FBSI «FSC for Medical and Preventive Health Risk Management Technologies»
  • Елена/Elena Алексеевна/Alekseevna Отавина/Otavina FBSI «FSC for Medical and Preventive Health Risk Management Technologies»
  • Инга/Inga Николаевна/Nicolaevna Аликина/Alikina FBSI «FSC for Medical and Preventive Health Risk Management Technologies»; Perm State University

Keywords:

continuous production cycle, gene polymorphism of carbohydrate and energy metabolism

Abstract

The aim of the research was to study the polymorphism of candidate genes in non-ferrous metallurgy workers, operating in night shifts regime. Genetic analysis is carried out using the polymerase chain reaction in real time with the evaluation results by the allelic discrimination. SNP-established violations according to the criterion of occurrence of variant alleles of genes of phase 1 detoxification, neuro-endocrine regulation and oncogenesis (excess performance comparison group for each group of genes in 1.5 times), the functions of carbohydrate and energy metabolism (in excess of the comparison group index of 2.0 times). Evaluation of immune status showed that the mode of work night shifts with conditions promote inhibition of the expression CD16 +, CD127- (1.2-1.5 times relative to the control group) and transcriptional activation of intracellular proteins Bcl-2 and bax (1.8-fold relative to the control group). Indicators of immune regulation (CD127-, Bcl-2, bax), as well as the Candidate alleles of genes CYP1A1 (1506C/T), TP53 (rs17884159), PPaARG (rs2016520) recommended for use as a marker of early indicators of health problems when working night shifts.

Author Biographies

  • Олег/Oleg Владимирович/Vladimirovich Долгих/Dolgikh, FBSI «FSC for Medical and Preventive Health Risk Management Technologies»; Perm State University; Perm National Research Polytechnic University
    Doctor of medical sciences, head of the Department of immunobiological diagnostic methods;Professor of the Department of human ecology and life safety;Professor of the Department of environmental protection
  • Александр/Alexandr Владимирович/Vladimirovich Кривцов/Krivtsov, FBSI «FSC for Medical and Preventive Health Risk Management Technologies»
    Candidate of medical sciences, head of the laboratory of immunogenetics
  • Ксения/Ksenia Геннадьевна/Gennadiyevna Старкова/Starkova, FBSI «FSC for Medical and Preventive Health Risk Management Technologies»
    Candidate of medical sciences head of the laboratory of immunology and allergology
  • Дмитрий/Dmitri Владимирович/Vladimirovich Ланин/Lanin, FBSI «FSC for Medical and Preventive Health Risk Management Technologies»; Perm State University
    Doctor of medical sciences, leading researcher of the Department of immunobiological diagnostic methods;Professor of the Department of human ecology and life safety
  • Ольга/Olga Алексеевна/Alekseevna Бубнова/Bubnova, FBSI «FSC for Medical and Preventive Health Risk Management Technologies»
    Junior researcher of the laboratory of immunogenetics; graduate student
  • Дина/Dina Гумерова/Gumerovna Дианова/Dianova, FBSI «FSC for Medical and Preventive Health Risk Management Technologies»
    Candidate of medical sciences, senior researcher at the Laboratory of cellular diagnostic methods
  • Елена/Elena Алексеевна/Alekseevna Отавина/Otavina, FBSI «FSC for Medical and Preventive Health Risk Management Technologies»
    Junior researcher of the laboratory of immunogenetics; graduate student
  • Инга/Inga Николаевна/Nicolaevna Аликина/Alikina, FBSI «FSC for Medical and Preventive Health Risk Management Technologies»; Perm State University
    Clinical research assistant of the laboratory of immunogenetics;Undergraduate of biological faculty

References

Горшкова К.Г. и др. Иммунологические и генетические маркеры внешнесредовой экспозиции стронцием // Санитарный врач. 2014. № 3. С. 72-74.

Долгих О.В. и др. Иммунологические и генетические маркеры воздействия ароматических углеводородов на работающих // Медицина труда и промышленная экология. 2012. № 12. С. 30-33.

Долгих О.В., Предеина Р.А., Дианова Д.Г. Экспериментальная оценка влияния фенолов на им-мунорегуляцию ex vivo // Анализ риска здоровью. 2014. № 1. С. 73-81.

Зайцева Н.В., Долгих О.В., Дианова Д.Г. Маркеры иммунного статуса у аппаратчиков, занятых на производстве активированных углей // Пермский медицинский журнал. 2011. Т. 28, № 5. С. 70-74.

Зайцева Н.В., Долгих О.В. Особенности клеточного звена иммунитета у детей в условиях внешне-средовой экспозиции толуолом, формальдегидом, фенолом // Известия Самарского научного центра Российской академии наук. 2012. Т. 14, № 5(2). C. 341-343.

Измеров Н. Ф. Профессиональный отбор в медицине труда // Медицина труда и промышленная экология. 2006. № 3. С. 1-5.

Dolgikh O. V. et. al. State of cell regulation in children exposed to phenols // Proceedings of the 3rd International Academic Conference «Applied and Fundamental Studies». 2013. P. 149-152.

Falchetti R. et. al. Effects of resveratrol on human immune cell function // Life Sci. 2001. Vol. 70, 1. Р. 81-96.

Gleichmann E. et. al. Immunotoxicilogy: suppressive and stimulatory effects of drugs and environmental chemicals on the immune system // Arch. Toxicology. 1989. № 63. P. 257-273.

References

Gorshkova K.G., Bubnova O.A., Maerova E.D., Dolgikh O.V. [Immunological and genetic markers of environmental exposure strontium]. Sanitarnyj vrac, N 3 (2014): pp. 72-74. (In Russ.).

Dolgikh O.V., Krivtsov A.V., Gugovich A.M. et al. [Immunologic and genetic markers of exposure to aromatic hydrocarbons in workers]. Medicina truda i promyslennaja ekologija, N 12 (2012): pp. 30-33. (In Russ.).

Dolgikh O.V., Predeina R.A., Dianova D.G. [Experimental assessment of phenol influence on immunoregulation ex vivo]. Analiz riska zdorovju, N 1 (2014): pp. 73-81. (In Russ.).

Zaitseva N.V., Dolgikh O.V., Dianova D.G.[Immune markers in operator of activated carbon production]. Permskij medicinskij zurnal, V. 28, N 5 (2011): pp. 70-74. (In Russ.).

Zaitseva N.V., Dolgikh O.V. [Features of children's cellular immunity in conditions of environmental exposure by toluene, formaldehyde, phenol]. Iz-vestija Samarskogo naucnogo centra RAN, V. 14, N 5 (2) (2012): pp. 341-343. (In Russ.).

Izmerov N.F. [Professional selection in occupational medicine]. Medicina truda i promyslennaja ekologija, N 3 (2006): pp. 1-5. (In Russ.).

Dolgikh O.V., Kharakhorina R.A., Dianova D.G., Gugovich A.M. State of cell regulation in children exposed to phenols. In: Proceedings of the 3rd International Academic Conference «Applied and Fundamental Studies». 2013. P. 149-152.

Falchetti R. et. al. Effects of resveratrol on human immune cell function. Life Sci. V. 70, 1 (2001): pp. 81-96.

Gleichmann E. et. al. Immunotoxicilogy: suppressive and stimulatory effects of drugs and environmental chemicals on the immune system. Arch. Toxicology, N 63 (1989): pp. 257-273.

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Published

2018-10-29

Issue

No. 2 (2017): Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology

Section

Клиническая лабораторная диагностика

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How to Cite

FEATURES OF GENETIC AND IMMUNOLOGICAL PARAMETERS IN THE WORKERS OF CONTINUOUS PRODUCTION CYCLE. (2018). Bulletin of Perm University. Biology, 2, 210-215. https://press.psu.ru/index.php/bio/article/view/1856

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