STUDY OF THE (+)-EROGORGIANE ANTIMICROBIAL ACTION MECHANISMS
Keywords:
erogorgiane, antibiotic, mycobacterium smegmatis, biofilmsAbstract
The antibacterial activity of a chemically synthesized counterpart of natural antibiotic (+) - erogorgiane extracted from marine coral Pseudopterogorgia elisabethae was studied. This substance has been shown to have bactericidal effect against Mycobacterium smegmatis culture in both logarithmic and stationary growth phases. At the same time, gram negative Escherichia coli is resistant to this compound. The concentration-dependent inhibition of M. smegmatis biofilm formation under sublethal antibiotic action has been observed. The effect of the test compound on the cell surface structure was detected with atomic force microscopy. The attempts to obtain antibiotic resistant mutants on agar media with high antibiotic concentrations failed.References
Aguayo S., Bozec L. Mechanics of bacterial bells and initial iurface colonisation // Advances in Experimental Medicine and Biology. 2016. Vol. 915. P. 245-260.
Ami M., Niikawa H., Kobayashi M. Marine-derived fungal sesterterpenes, ophiobolins, inhibit biofilm formation of Mycobacterium species // Journal of Natural Medicines. 2013. Vol. 67, № 2. P. 271-275.
De Souza M. V.N. Marine natural products against tuberculosis // The Scientific World Journal. 2006. Vol. 21, №6. P. 847-861.
Kern W.V., Oethinger M., Jellen-Ritter A.S., Levy S.B. Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli // Antimicrobial Agents and Chemotherapy. 2000. Vol. 44, № 4. P. 814—820.
Leisner J.J., Jorgensen N.O., Middelboe M. Predation and selection for antibiotic resistance in natural environments // Evolutionary Applications Journal. 2016. Vol. 9, № 3. P. 427-434.
McMurry L.M., McDermott P.F., Levy S.B. Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan // Antimicrobial Agents and Chemotherapy. 1999. Vol. 43, № 3. P. 711-713.
Migliori G.B., Sotgiu G., Gandhi N.R. et al. Drug resistance beyond extensively drug-resistant tuberculosis: individual patient data meta-analysis // European Respiratory Journal. 2013. Vol. 42, № 1. P. 169-179.
Sharma I.M., Petchiappan A., Chatterji D. Quorum sensing and biofilm formation in mycobacteria: role of c-di-GMP and methods to study this second messenger // International Union of Biochemistry and Molecular Biology Life. 2014. Vol. 66, № 12. P. 823-834.
Syal K., Maiti K., Naresh K. et al. Synthetic arabino-mannan glycolipids impede mycobacterial growth, sliding motility and biofilm structure // Glycoconju-gate Journal. 2016. № 4.
Telenti A., Honoré N., Bernasconi C. et al. Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level // Journal of Clinical Microbiology. 1997. Vol. 35, № 3. P. 719-723.
World Health Organisation. Global Tuberculosis report 2015. France, 2015. 192 p.
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Aguayo S., Bozec L. Mechanics of bacterial cells and initial surface colonization. Advances in Experimental Medicine and Biology. V. 915 (2016): pp. 245-260.
Arai M., Niikawa H., Kobayashi M. Marine-derived fungal sesterterpenes, ophiobolins, inhibit biofilm formation of Mycobacterium species. Journal of Natural Medicines. V. 67 No. 2 (2013): pp. 271-275.
De Souza M.V.N. Marine natural products against tuberculosis. The Scientific World Journal. V. 21 No. 6 (2006): pp. 847-861.
Kern W.V., Oethinger M., Jellen-Ritter A., Levy S.V. Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli. Antimicrobial Agents and Chemotherapy. V. 44 No. 4 (2000): pp. 814-820.
Leisner J.J., Jorgensen N.O., Middelboe M. Prédation and selection for antibiotic resistance in natural environments. Evolutionary Applications Journal. V. 9 No. 3 (2016): pp. 427-434.
McMurry L.M., McDermott P.F., LevyS.B. Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan. Antimicrobial Agents and Chemotherapy. V. 43 No. 3 (1999): pp. 711-713.
Migliori G.B., Sotgiu G., Gandhi N.R., Falzon D., DeRiemer К. Drug resistance beyond extensively drug-resistant tuberculosis: individual patient data meta-analysis. European Respiratory Journal. V. 42 No. 1 (2013): pp. 169-179.
Sharma I.M., Petchiappan A., Chatterji D. Quorum sensing and biofilm formation in mycobacteria: role of c-di-GMP and methods to study this second messenger. International Union of Biochemistry and Molecular Biology Life. V. 66 No. 12 (2014): pp. 823-834.
Syal K., Maiti K., Naresh K., Avaji P.G., Chatterji D., Jayaraman N. Synthetic arabinomannan glycolipids impede mycobacterial growth, sliding motility and biofilm structure. Glycoconjugate Journal. No. 4 (2016).
Telenti A., Honoré N., Bernasconi C., March J., Ortega A., Heym В., Takiff H.E., Cole S.T. Genotypic assessment of isoniazid and rifampin resistance in Mycobacterium tuberculosis: a blind study at reference laboratory level. Journal of Clinical Microbiology. V. 35 No. 3 (1997): pp. 719-723.
World Health Organisation. Global Tuberculosis report 2015. France, 2015. 192 p.
