Современные подходы к управлению фенотипическим балансом макрофагов для модуляции иммунитета при хроническом воспалении
DOI:
https://doi.org/10.17072/1994-9952-2026-2-213-224Ключевые слова:
Цитокины, иммуномодуляция, иммунные клетки, активация макрофаговАннотация
Заживление ран кожного покрова представляет собой каскад сложных биологических процессов, обеспечивающих восстановление тканей, одним из ключевых звеньев которого является поляризация макрофагов, регулирующая переход от воспалительного к противовоспалительному состоянию. Нарушения этого процесса приводят к хроническому воспалению, фиброзу и затягиванию восстановления тканей. Современные исследования, направленные на коррекцию микроокружения в раневом ложе посредством иммуномодуляции, сосредоточены на использовании цитокинов и факторов роста, таких как IL-4, IL-10, PDGF, VEGF, IGF-1, FGF-10 и др., для модуляции активности макрофагов. Все эти биомолекулы, включенные в наноматериалы и системы доставки, способствуют ускорению заживления, снижению рубцевания и регулированию воспаления. В онкологии и воспалительных заболеваниях также изучается возможность переключения макрофагов между М1/М2 фенотипами для достижения терапевтических целей. Эффективность таких подходов повышается за счет использования современных носителей, обеспечивающих целевую доставку и регуляцию высвобождения цитокинов. В данной работе рассматриваются современные достижения применения цитокинов и факторов роста включенных в различные системы для модуляции макрофагов и их фенотипов, и использования их для разработки персонализированных и эффективных методов лечения как различных патологий, так и в особенности повреждений кожного покрова.Библиографические ссылки
Список источников
1. Быкова Н.И. и др. Индексная оценка клинической эффективности иммуномодулирующей и остеотропной терапии хронического генерализованного пародонтита различной степени тяжести: проспективное когортное исследование // Кубанский научный медицинский вестник. 2023. Т. 30, № 3. C. 34–43. DOI: 10.25207/1608-6228-2023-30-3-34-43. EDN: FBNFWW
2. Нестерова И.В., Халтурина Е.О. Эффективность дифференцированной таргетной интерферонои иммуномодулирующей терапии, ориентированной на патологические иммунофенотипы, у пациентов с атипичными хроническими активными герпесвирусными инфекциями // Медицинский вестник Юга России. 2024. Т. 15, № 1. C. 165–175. DOI: 10.21886/2219-8075-2024-15-1-165-175. EDN: XLATOE
3. Федоров А.А. и др. Поляризация макрофагов: механизмы, маркеры и факторы индукции // Си-бирский онкологический журнал. 2022. Т. 21, № 4. C. 124–136. DOI: 10.21294/1814-4861-2022-21-4-124-136. EDN: LYBKUG
4. Aitcheson S.M et al. Skin wound healing: normal macrophage function and macrophage dysfunction in diabetic wounds // Molecules. 2021. Vol. 26, № 16. Art. 4917. DOI: 10.3390/molecules26164917.
5. Aktay-Cetin Ö. et al. Lung tumor immunity: redirecting macrophages through infection-induced in-flammation // Trends in Immunology. 2025. Vol. 46, № 6. P. 471–484. DOI: 10.1016/j.it.2025.04.004.
6. Barman P.K., Koh T.J. Macrophage dysregulation and impaired skin wound healing in diabetes // Frontiers in cell and developmental biology. 2020. Vol. 8. Art. 528. DOI: 10.3389/fcell.2020.00528.
7. Cao X. et al. IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE2-mediated M2 macrophage polarization // Theranostics. 2020. Vol. 10, № 17. P. 7697–7709. DOI: 10.7150/thno.45434.
8. Chen R. et al. Overexpression of CD86 enhances the ability of THP‐1 macrophages to defend against Talaromyces marneffei // Immunity, inflammation and disease. 2022. Vol. 10, № 12. Art. e740. DOI: 10.1002/iid3.740.
9. Chen S. et al. CD40 induces PIR-A+ macrophages to promote chronic allograft rejection // Interna-tional Immunopharmacology. 2025. Vol. 150. Art. 114274. DOI: 10.1016/j.intimp.2025.114274.
10. Chen Y. et al. Engineered IFNγ-loaded exosomes reprogram macrophage polarization and suppress tumor cell proliferation in vitro // International Immunopharmacology. 2025. Vol. 162. Art. 115170. DOI: 10.1016/j.intimp.2025.115170.
11. Delprat V. et al. Csycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway // Scientific reports. 2020. Vol. 10, № 1. Art. 882. DOI: 10.1038/s41598-020-57677-5.
12. Deng T. et al. Immunomodulatory effects of curcumin on macrophage polarization in rheumatoid arthritis // Frontiers in Pharmacology. 2024. Vol. 15. Art. 1369337. DOI: 10.3389/fphar.2024.1369337.
13. El Ayadi A., Jay J.W., Prasai A. Current approaches targeting the wound healing phases to attenuate fibrosis and scarring // International journal of molecular sciences. 2020. Vol. 21, № 3. Art. 1105. DOI: 10.3390/ijms21031105.
14. Feng N. et al. Fibroblast growth factor 10 alleviates LPS-induced acute lung injury by promoting re-cruited macrophage M2 polarization // Inflammation. 2025. Vol. 48, № 4. P. 1828–1838. DOI: 10.1007/s10753-024-02158-4.
15. Gao L. et al. Dual‐inflammatory cytokines on TiO2 nanotube‐coated surfaces used for regulating macrophage polarization in bone implants // Journal of Biomedical Materials Research Part A. 2018. Vol. 106, № 7. P. 1878–1886. DOI: 10.1002/jbm.a.36391.
16. Gu H. et al. NLRP3 activation in tumor-associated macrophages enhances lung metastasis of pan-creatic ductal adenocarcinoma // Translational Lung Cancer Research. 2022. Vol. 11, № 5. P. 858–868. DOI: 10.21037/tlcr-22-311.
17. He T. et al. Modulation of macrophage function by bioactive wound dressings with an emphasis on extracellular matrix-based scaffolds and nanofibrous composites // Pharmaceutics. 2023. Vol. 5, № 3. Art. 794. DOI: 10.3390/pharmaceutics15030794.
18. Ishida K. et al. Induction of unique macrophage subset by simultaneous stimulation with LPS and IL-4 // Frontiers in immunology. 2023. Vol. 14. Art. 1111729. DOI: 10.3389/fimmu.2023.1111729.
19. Jinno M. et al. Involvement of muscarinic M3 receptor in the development of M2 macrophages in allergic inflammation // International Archives of Allergy and Immunology. 2024. Vol. 185, № 8. P. 729–738. DOI: 10.1159/000538126.
20. Joorabloo A., Liu T. Recent advances in nanomedicines for regulation of macrophages in wound healing // Journal of nanobiotechnology. 2022. Vol. 20, № 1. Art. 407. DOI: 10.1186/s12951-022-01616-1.
21. Kathawala M.H. et al. Healing of chronic wounds: an update of recent developments and future possibilities // Tissue engineering part B: Reviews. 2019. Vol. 25, № 5. P. 429–444. DOI: 10.1089/ten.TEB.2019.0019.
22. Kim S.W. et al. Reprogramming of tumor-associated macrophages by metabolites generated from tumor microenvironment // Animal Cells and Systems. 2024. Vol. 28, № 1. P. 123–136. DOI: 10.1080/19768354.2024.2336249.
23. Kuan C.H. et al. Immunomodulatory hydrogel orchestrates pro-regenerative response of macro-phages and angiogenesis for chronic wound healing // Biomaterials. 2025. Vol. 314. Art. 122848. DOI: 10.1016/j.biomaterials.2024.122848.
24. Kulakova K. et al. The contribution of macrophage plasticity to inflammatory arthritis and their po-tential as therapeutic targets // Cells. 2024. Vol. 13, № 18. Art. 1586. DOI: 10.3390/cells13181586.
25. Lee Z.T. et al. Dexamethasone-Induced MerTK+/high M2c Macrophages Exhibit a Preference for Downregulated Gene Expression Profiles // Journal of Genomics. 2025. Vol. 13. Art. 24. DOI: 10.7150/jgen.108648.
26. Li S. et al. IL-25 improves diabetic wound healing through stimulating M2 macrophage polarization and fibroblast activation // International immunopharmacology. 2022. Vol. 106. Art. 108605. DOI: 10.1016/j.intimp.2022.108605.
27. Lou X. et al. IL-36α inhibits melanoma by inducing pro-inflammatory polarization of macrophages // Cancer Immunology, Immunotherapy. 2023. Vol. 72, № 9. P. 3045–3061. DOI: 10.1007/s00262-023-03477-5.
28. Luchian I. et al. The role of matrix metalloproteinases (MMP-8, MMP-9, MMP-13) in periodontal and peri-implant pathological processes // International journal of molecular sciences. 2022. Vol. 23, № 3. Art. 1806. DOI: 10.3390/ijms23031806.
29. Luo M. et al. Macrophage polarization: an important role in inflammatory diseases // Frontiers in immunology. 2024. Vol. 15. Art. 1352946. DOI: 10.3389/fimmu.2024.1352946.
30. Mamilos A. et al. Macrophages: from simple phagocyte to an integrative regulatory cell for inflam-mation and tissue regeneration-a review of the literature // Cells. 2023. Vol. 12, № 2. Art. 276. DOI: 10.3390/cells12020276.
31. Mao J. et al. Advanced biomaterials for regulating polarization of macrophages in wound healing // Advanced Functional Materials. 2022. Vol. 32, № 12. Art. 2111003. DOI: 10.1002/adfm.202111003.
32. Nielsen M.C. et al. Macrophage activation markers, CD163 and CD206, in acute-on-chronic liver failure // Cells. 2020. Vol. 9, № 5. Art. 1175. DOI: 10.3390/cells9051175.
33. Oates T.C.L. et al. Characterizing the polarization continuum of macrophage subtypes M1, M2a and M2c // BioRxiv. 2022. Art. 95868. DOI: 10.1101/2022.06.13.495868.
34. Piipponen M., Li D., Landén N.X. The immune functions of keratinocytes in skin wound healing // International journal of molecular sciences. 2020. Vol. 21, № 22. Art. 8790. DOI: 10.3390/ijms21228790.
35. Raziyeva K. et al. Immunology of acute and chronic wound healing // Biomolecules. 2021. Vol. 11, № 5. Art. 700. DOI: 10.3390/biom11050700.
36. Rehak L. et al. The immune-centric revolution in the diabetic foot: monocytes and lymphocytes role in wound healing and tissue regeneration-a narrative review // Journal of Clinical Medicine. 2022. Vol. 11, № 3. Art. 889. DOI: 10.3390/jcm11030889.
37. Ross E.A., Devitt A., Johnson J.R. Macrophages: the good, the bad, and the gluttony // Frontiers in immunology. 2021. Vol. 12. Art. 708186. DOI: 10.3389/fimmu.2021.708186.
38. Scopelliti F. et al. Platelet lysate converts M (IFNγ+ LPS) macrophages in CD206+ TGF‐β+ ar-ginase+ M2‐like macrophages that affect fibroblast activity and T lymphocyte migration // Journal of Tis-sue Engineering and Regenerative Medicine. 2021. Vol. 15, № 9. P. 788–797. DOI: 10.1002/term.3229.
39. Shahbazi M.A. et al. Targeted reinforcement of macrophage reprogramming toward M2 polarization by IL-4-loaded hyaluronic acid particles // ACS Omega. 2018. Vol. 3, № 12. P. 18444–18455. DOI: 10.1021/acsomega.8b03182.
40. Sharifiaghdam M. et al. Macrophages as a therapeutic target to promote diabetic wound healing // Molecular Therapy. 2022. Vol. 30, № 9. P. 2891–2908. DOI: 10.1016/j.ymthe.2022.07.016.
41. Shen D., Chen J. Cardiac macrophages promote polarization of macrophages toward M2 phenotype to improve myocardial remodeling via NGAL after myocardial infarction // Cell Biochemistry and Bio-physics. 2025. Vol. 83. P. 3427–3436. DOI: 10.1007/s12013-025-01726-1.
42. Silveira M.J. et al. Immunostimulatory effects of IL-12 targeted pH-responsive nanoparticles in macrophage-enriched 3D immuno-spheroids in vitro model // Drug Delivery and Translational Research. 2025. Vol. 15. P. 4775–4794. DOI: 10.1007/s13346-025-01896-8.
43. Singer M. et al. Modulation of tumor-associated macrophages to overcome immune suppression in the hepatocellular carcinoma microenvironment // Cancers. 2024. Vol. 17, № 1. Art. 66. DOI: 10.3390/cancers17010066.
44. Tian G. et al. Cell-free decellularized cartilage extracellular matrix scaffolds combined with inter-leukin 4 promote osteochondral repair through immunomodulatory macrophages: in vitro and in vivo pre-clinical study // Acta biomaterialia. 2021. Vol. 127. P. 131–145. DOI: 10.1016/j.actbio.2021.03.054.
45. Torregrossa M. et al. Modulation of macrophage functions by ECM-inspired wound dressings–a promising therapeutic approach for chronic wounds // Biological chemistry. 2021. Vol. 402, № 11. P. 1289–1307. DOI: 10.1515/hsz-2021-0145.
46. Tottoli E.M. Skin wound healing process and new emerging technologies for skin wound care and regeneration // Pharmaceutics. 2020. Vol. 12, № 8. Art. 735. DOI: 10.3390/pharmaceutics12080735.
47. Walvekar K.P. et al. Stable expression of human arginase 1 does not suppress inflammation or M1 macrophage polarization in THP-1 monocytes // Next Research. 2025. Vol. 2, № 3. Art. 100656. DOI: 10.1016/j.nexres.2025.100656.
48. Xiaoye Z.H.U. et al. Role of M1/M2 macrophages in pain modulation // Journal of Central South University Medical Sciences. 2024. Vol. 49, № 7. Art. 1155. DOI: 10.11817/j.issn.16727347.2024.240017.
49. Xin Y. et al. Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles allevi-ates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization through LIF-mediated JAK1–STAT3 signaling // Frontiers in Immunology. 2025. Vol. 16. Art. 1577349. DOI: 10.3389/fimmu.2025.1577349.
50. Yu Y. et al. Macrophages play a key role in tissue repair and regeneration // Peer J. 2022. Vol. 10. Art. 14053. DOI: 10.7717/peerj.14053.
51. Zeng Q.L., Liu D.W. Mesenchymal stem cell-derived exosomes: An emerging therapeutic strategy for normal and chronic wound healing // World journal of clinical cases. 2021. Vol. 9, № 22. Art. 6218. DOI: 10.12998/wjcc.v9.i22.6218.
52. Zhang Q., Sioud M. Tumor-associated macrophage subsets: shaping polarization and targeting // In-ternational journal of molecular sciences. 2023. Vol. 24, № 8. Art. 7493. DOI: 10.3390/ijms24087493.
53. Zhang S. et al. Bufei Jiedu Formula enhances CD40 activation and macrophage polarization to elim-inate intracellular MRSA persisters // Frontiers in Immunology. 2025. Vol. 16. Art. 1623182. DOI: 10.3389/fimmu.2025.1623182.
References
1. Bykova N.I. et al. [Index evaluation of clinical efficacy of immunomodulatory and osteotropic thera-py for chronic generalized periodontitis of varying severity: a prospective cohort study]. Kubanskij naučnyj medicinskij vestnik. V. 30, No. 3 (2023): pp. 35-43. (In Russ.). DOI: 10.25207/1608-6228-2023-30-3-34-43. EDN: FBNFWW
2. Nesterova I.V., Khalturina E.O. [Efficacy of differentiated targeted interferon and immunomodulato-ry therapy focused on pathological immunophenotypes in patients with atypical chronic active herpesvi-rus infections]. Medicinskij vestnik Juga Rossii. V. 15, No. 1 (2024): pp. 165-175. (In Russ.). DOI 10.21886/2219-8075-2024-15-1-165-175. EDN: XLATOE
3. Fedorov A.A. et al. [Polarization of macrophages: mechanisms, markers and factors of induction]. Sibirskij onkologičeskij žurnal. V. 21, No. 4 (2022): pp. 124-136. (In Russ.). DOI: 10.21294/1814-4861-2022-21-4-124-136. EDN: LYBKUG
4. Aitcheson S.M et al. Skin wound healing: normal macrophage function and macrophage dysfunction in diabetic wounds. Molecules. V. 26, No. 16 (2021). Art. 4917. DOI: 10.3390/molecules26164917.
5. Aktay-Cetin Ö. et al. Lung tumor immunity: redirecting macrophages through infection-induced in-flammation. Trends in Immunology. V. 46, No. 6 (2025): pp. 471-484. DOI: 10.1016/j.it.2025.04.004.
6. Barman P.K., Koh T.J. Macrophage dysregulation and impaired skin wound healing in diabetes. Frontiers in cell and developmental biology. V. 8 (2020). Art. 528. DOI: 10.3389/fcell.2020.00528.
7. Cao X. et al. IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE2-mediated M2 macrophage polarization. Theranostics. V. 10, No. 17 (2020): pp. 7697-7709. DOI: 10.7150/thno.45434.
8. Chen R. et al. Overexpression of CD86 enhances the ability of THP‐1 macrophages to defend against Talaromyces marneffei. Immunity, inflammation and disease. V. 10, No. 12 (2022). Art. e740. DOI: 10.1002/iid3.740.
9. Chen S. et al. CD40 induces PIR-A+ macrophages to promote chronic allograft rejection. Interna-tional Immunopharmacology. V. 150 (2025). Art. 114274. DOI: 10.1016/j.intimp.2025.114274.
10. Chen Y. et al. Engineered IFNγ-loaded exosomes reprogram macrophage polarization and suppress tumor cell proliferation in vitro. International Immunopharmacology. V. 162 (2025). Art. 115170. DOI: 10.1016/j.intimp.2025.115170.
11. Delprat V. et al. Csycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway. Scientific reports. V. 10, No. 1 (2020). Art. 882. DOI: 10.1038/s41598-020-57677-5.
12. Deng T. et al. Immunomodulatory effects of curcumin on macrophage polarization in rheumatoid arthritis. Frontiers in Pharmacology. V. 15. (2024). Art. 1369337. DOI: 10.3389/fphar.2024.1369337.
13. El Ayadi A., Jay J.W., Prasai A. Current approaches targeting the wound healing phases to attenuate fibrosis and scarring. International journal of molecular sciences. V. 21, No. 3 (2020). Art. 1105. DOI: 10.3390/ijms21031105.
14. Feng N. et al. Fibroblast growth factor 10 alleviates LPS-induced acute lung injury by promoting re-cruited macrophage M2 polarization. Inflammation. V . 48, No. 4 (2025): P. 1828-1838. DOI: 10.1007/s10753-024-02158-4.
15. Gao L. et al. Dual‐inflammatory cytokines on TiO2 nanotube‐coated surfaces used for regulating macrophage polarization in bone implants. Journal of Biomedical Materials Research Part A. V. 106, No. 7 (2018): pp. 1878-1886. DOI: 10.1002/jbm.a.36391.
16. Gu H. et al. NLRP3 activation in tumor-associated macrophages enhances lung metastasis of pan-creatic ductal adenocarcinoma. Translational Lung Cancer Research. V. 11, No. 5 (2022): pp. 858-868. DOI: 10.21037/tlcr-22-311.
17. He T. et al. Modulation of macrophage function by bioactive wound dressings with an emphasis on extracellular matrix-based scaffolds and nanofibrous composites. Pharmaceutics. V. 5, No. 3 (2023). Art. 794. DOI: 10.3390/pharmaceutics15030794.
18. Ishida K. et al. Induction of unique macrophage subset by simultaneous stimulation with LPS and IL-4. Frontiers in immunology. V. 14 (2023). Art. 1111729. DOI: 10.3389/fimmu.2023.1111729.
19. Jinno M. et al. Involvement of muscarinic M3 receptor in the development of M2 macrophages in allergic inflammation. International Archives of Allergy and Immunology. V. 185, No. 8 (2024): pp. 729-738. DOI: 10.1159/000538126.
20. Joorabloo A., Liu T. Recent advances in nanomedicines for regulation of macrophages in wound healing. Journal of nanobiotechnology. V. 20, No. 1 (2022). Art. 407. DOI: 10.1186/s12951-022-01616-1.
21. Kathawala M.H. et al. Healing of chronic wounds: an update of recent developments and future possibilities. Tissue engineering part B: Reviews. V. 25, No. 5 (2019): pp. 429-444. DOI: 10.1089/ten.TEB.2019.0019.
22. Kim S.W. et al. Reprogramming of tumor-associated macrophages by metabolites generated from tumor microenvironment. Animal Cells and Systems. V. 28, No. 1 (2024): pp. 123-136. DOI: 10.1080/19768354.2024.2336249.
23. Kuan C.H. et al. Immunomodulatory hydrogel orchestrates pro-regenerative response of macro-phages and angiogenesis for chronic wound healing. Biomaterials. V. 314 (2025). Art. 122848. DOI: 10.1016/j.biomaterials.2024.122848.
24. Kulakova K. et al. The contribution of macrophage plasticity to inflammatory arthritis and their po-tential as therapeutic targets. Cells. V. 13, No. 18 (2024). Art. 1586. DOI: 10.3390/cells13181586.
25. Lee Z.T. et al. Dexamethasone-Induced MerTK+/high M2c Macrophages Exhibit a Preference for Downregulated Gene Expression Profiles. Journal of Genomics. V. 13 (2025). Art. 24. DOI: 10.7150/jgen.108648.
26. Li S. et al. IL-25 improves diabetic wound healing through stimulating M2 macrophage polarization and fibroblast activation. International immunopharmacology. V. 106 (2022). Art. 108605. DOI: 10.1016/j.intimp.2022.108605.
27. Lou X. et al. IL-36α inhibits melanoma by inducing pro-inflammatory polarization of macrophages. Cancer Immunology, Immunotherapy. V. 72, No. 9 (2023): pp. 3045-3061. DOI: 10.1007/s00262-023-03477-5.
28. Luchian I. et al. The role of matrix metalloproteinases (MMP-8, MMP-9, MMP-13) in periodontal and peri-implant pathological processes. International journal of molecular sciences. V. 23, No. 3 (2022). Art. 1806. DOI: 10.3390/ijms23031806.
29. Luo M. et al. Macrophage polarization: an important role in inflammatory diseases. Frontiers in immunology. Vol. (2024). Art. 1352946. DOI: 10.3389/fimmu.2024.1352946.
30. Mamilos A. et al. Macrophages: from simple phagocyte to an integrative regulatory cell for inflam-mation and tissue regeneration-a review of the literature. Cells. V. 12, No. 2 (2023). Art. 276. DOI: 10.3390/cells12020276.
31. Mao J. et al. Advanced biomaterials for regulating polarization of macrophages in wound healing. Advanced Functional Materials. V. 32, No. 12 (2022). Art. 2111003. DOI: 10.1002/adfm.202111003.
32. Nielsen M.C. et al. Macrophage activation markers, CD163 and CD206, in acute-on-chronic liver failure. Cells. V. 9, No. 5 (2020). Art. 1175. DOI: 10.3390/cells9051175.
33. Oates T.C.L. et al. Characterizing the polarization continuum of macrophage subtypes M1, M2a and M2c. BioRxiv. 2022. Art. 95868. DOI: 10.1101/2022.06.13.495868.
34. Piipponen M., Li D., Landén N.X. The immune functions of keratinocytes in skin wound healing. In-ternational journal of molecular sciences. V. 21, No. 22 (2020). Art. 8790. DOI: 10.3390/ijms21228790.
35. Raziyeva K. et al. Immunology of acute and chronic wound healing. Biomolecules. V. 11, No. 5 (2021). Art. 700. DOI: 10.3390/biom11050700.
36. Rehak L. et al. The immune-centric revolution in the diabetic foot: monocytes and lymphocytes role in wound healing and tissue regeneration-a narrative review. Journal of Clinical Medicine. V. 11, No. 3 (2022). Art. 889. DOI: 10.3390/jcm11030889.
37. Ross E.A., Devitt A., Johnson J.R. Macrophages: the good, the bad, and the gluttony. Frontiers in immunology. V. 12 (2021). Art. 708186. DOI: 10.3389/fimmu.2021.708186.
38. Scopelliti F. et al. Platelet lysate converts M (IFNγ+ LPS) macrophages in CD206+ TGF‐β+ ar-ginase+ M2‐like macrophages that affect fibroblast activity and T lymphocyte migration. Journal of Tissue Engineering and Regenerative Medicine. V. 15, No 9 (2021): pp. 788-797. DOI: 10.1002/term.3229.
39. Shahbazi M.A. et al. Targeted reinforcement of macrophage reprogramming toward M2 polarization by IL-4-loaded hyaluronic acid particles. ACS Omega. V. 3, No. 12 (2018): pp. 18444-18455. DOI: 10.1021/acsomega.8b03182.
40. Sharifiaghdam M. et al. Macrophages as a therapeutic target to promote diabetic wound healing. Molecular Therapy. V. 30, No. 9 (2022): pp. 2891-2908. DOI: 10.1016/j.ymthe.2022.07.016.
41. Shen D., Chen J. Cardiac macrophages promote polarization of macrophages toward M2 phenotype to improve myocardial remodeling via NGAL after myocardial infarction. Cell Biochemistry and Biophys-ics. V. 83 (2025): pp. 3427-3436. DOI: 10.1007/s12013-025-01726-1.
42. Silveira M.J. et al. Immunostimulatory effects of IL-12 targeted pH-responsive nanoparticles in macrophage-enriched 3D immuno-spheroids in vitro model. Drug Delivery and Translational Research. V. 15 (2025): pp. 4775-4794. DOI: 10.1007/s13346-025-01896-8.
43. Singer M. et al. Modulation of tumor-associated macrophages to overcome immune suppression in the hepatocellular carcinoma microenvironment. Cancers. V. 17, No. 1 (2024). Art. 66. DOI: 10.3390/cancers17010066.
44. Tian G. et al. Cell-free decellularized cartilage extracellular matrix scaffolds combined with inter-leukin 4 promote osteochondral repair through immunomodulatory macrophages: in vitro and in vivo pre-clinical study. Acta biomaterialia. V. 127 (2021): pp. 131-145. DOI: 10.1016/j.actbio.2021.03.054.
45. Torregrossa M. et al. Modulation of macrophage functions by ECM-inspired wound dressings–a promising therapeutic approach for chronic wounds. Biological chemistry. V. 402, No. 11 (2021): pp. 1289-1307. DOI: 10.1515/hsz-2021-0145.
46. Tottoli E.M. Skin wound healing process and new emerging technologies for skin wound care and regeneration. Pharmaceutics. V. 12. No. 8 (2020). Art. 735. DOI: 10.3390/pharmaceutics12080735.
47. Walvekar K.P. et al. Stable expression of human arginase 1 does not suppress inflammation or M1 macrophage polarization in THP-1 monocytes. Next Research. V. 2, No. 3 (2025). Art. 100656. DOI: 10.1016/j.nexres.2025.100656.
48. Xiaoye Z.H.U. et al. Role of M1/M2 macrophages in pain modulation. Journal of Central South University Medical Sciences. V. 49, No. 7 (2024). Art. 1155. DOI: 10.11817/j.issn.16727347.2024.240017.
49. Xin Y. et al. Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles allevi-ates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization through LIF-mediated JAK1–STAT3 signaling. Frontiers in Immunology. V. 16 (2025). Art. 1577349. DOI: 10.3389/fimmu.2025.1577349.
50. Yu Y. et al. Macrophages play a key role in tissue repair and regeneration. PeerJ. V. 10 (2022). Art. 14053. DOI: 10.7717/peerj.14053.
51. Zeng Q.L., Liu D.W. Mesenchymal stem cell-derived exosomes: An emerging therapeutic strategy for normal and chronic wound healing. World journal of clinical cases. V. 9, No. 22 (2021). Art. 6218. DOI: 10.12998/wjcc.v9.i22.6218.
52. Zhang Q., Sioud M. Tumor-associated macrophage subsets: shaping polarization and targeting. In-ternational journal of molecular sciences. V. 24, No. 8 (2023). Art. 7493. DOI: 10.3390/ijms24087493.
53. Zhang S. et al. Bufei Jiedu Formula enhances CD40 activation and macrophage polarization to elim-inate intracellular MRSA persisters. Frontiers in Immunology. V. 16 (2025). Art. 1623182. DOI: 10.3389/fimmu.2025.1623182.
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Лицензионный договор на право использования научного произведения в научных журналах, учредителем которых является Пермский государственный национальный исследовательский университет
Текст Договора размещен на сайте Пермского государственного национального исследовательского университета http://www.psu.ru/, а также его можно получить по электронной почте в «Отделе научных периодических и продолжающихся изданий ПГНИУ»: YakshnaN@psu.ru или в редакциях научных журналов ПГНИУ.
