IMMUNOLOGICAL PATHWAYS OF DEVELOPMENT OF EXPERIMENTAL ACQUIRED TOXIC HEMOLYTIC
Keywords:
autoimmune hemolytic anemia, 2-butoxyethanol, haematotoxicityAbstract
Toxic hemolytic anemia, induced by drugs and industrial reagents, is provided by combination of different pathogenetic mechanisms. 2-butoxyethanol, a widely used in chemical industry reagent and strong hemolytic poison, was taken for modeling toxic hemolytic anemia. 2-butoxyethanol was injected to white nonlinear rats intraperitoneally. We were taken venous blood for erythrocyte suspension before the experiment. After 10 days we carried out serum agglutination test with autologous erythrocytes. In peripheral blood was found significant decreasing in hemoglobin level and reducing of red blood cells number, increasing in number of reticulocytes. In serum agglutination test was observed the presence of antibodies to own erythrocytes both in group with injection of 2-butoxythanol and in group with injection of 2-butoxyethanol in combination with acute cold stress. It shows the development of autoimmune reaction to own red blood cells. In serum agglutination test with heterologous erythrocytes reaction was positive in control group with average values log - 2,5±1,3. It is explained by genetical identity in outbred population of laboratory rats.References
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References
Baier J.E., Poehlau D. Is alpha-methyldopa-type autoimmune hemolytic anemia mediated by inter-feron-gamma? Annals of Hematology. 1994, Nov; 69(5): 249-51.
Baker H.J., Lindsey J.R., Weisbroth S.H. The Laboratory Rat, Volume I: Biology and Disease. New York: Academic Press; 1979: 55-57.
Berger J. Phenylhydrazine haematotoxicity. J Appl Biomed. 2007; 5: 125-30.
Betensky M., Witmer C., Fisher M.J., Nance S., Weiss M.J., Sesok-Pizzini D.A. Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma. Transfusion. 2014; 54 (11): 2901-2905.
Bollotte A., Vial T., Bricca P., Bernard C., Broussolle C., Sève P. Drug-induced hemolytic anemia: A retrospective study of 10 cases. Rev Med Interne. 2014; 35(12): 779-89.
El-Ashmawy I.M., Gad S.B., Salama O.M. Grape seed extract prevents azathioprine toxicity in rats. Phytother Res. 2010; 24(11): 1710-1715.
Exon J.H., Mather G.G., Bussiere J.L., Olson D.P., Talcott P.A. Effects of subchronic exposure of rats to 2-methoxyethanol or 2-butoxyethanol: thymic atrophy and immunotoxicity. Fundam Appl Toxicol. 1991 May; 16 (4): 830-40.
Garratty G., Arndt P.A. An update on drug-induced immune hemolytic anemia. Immunohematology. 2007; 23(3): 105-19.
Garratty G. Drug-induced immune hemolytic anemia. ASH Education Book January. 2009; 1: 73-79.
Ghanayem B.I., Sanchez I.M., Matthews H.B. Development of tolerance to 2-butoxyethanol-induced hemolytic anemia and studies to elucidate the underlying mechanisms. Toxicol Appl Pharmacol. 1992 Feb; 112 (2): 198-206.
Ghanayem B.I., Sullivan C.A. Assessment of the haemolytic activity of 2-butoxyethanol and its major metabolite, butoxyacetic acid, in various mammals including humans. Hum Exp Toxicol. 1993 Jul; 12 (4): 305-11.
Haddad H., Mohammad F., Dai Q. Bendamustine-induced immune hemolytic anemia in a chronic lymphocytic leukemia patient: A case report and review of the literature. Hematol Oncol Stem Cell Ther. 2014 Dec; 7(4): 162-4.
Haley K.M., Russell Th.B., Boshkov L., Leger R.M., Garratty G., Recht M. et al. Fatal carboplatin-induced immune hemolytic anemia in a child with a brain tumor. J. Blood Med. 2014; 15(5): 55-8.
Hillman R.S., Ault K.A., Rinder H.M. Hematology in Clinical Practice, 4th Edition. 2005: 135-151.
Hematology: basic principles and practice / R. Hoffman et al. 5th ed. 2008: pp. 645-659.
Horn S., Bashan N., Gopas J. Phagocytosis of phenyl-hydrazine oxidized and G-6-PD-deficient red blood cells: the role of cell-bound immunoglobulins. Blood. 1991 Oct 1; 78 (7): 1818-25.
Johnson S.T., Fueger J.T., Gottschall J.L. One center's experience: the serology and drugs associated with drug-induced immune hemolytic anemia - a new paradigm. Transfusion. 2007; 47(4): 697-702.
Joybari A.Y., Sarbaz S., Azadeh P., Mirafsharieh S.A., Rahbari A., Farasatinasab M. et al. Ox-aliplatin-induced renal tubular vacuolization. Ann Pharmacother. 2014; 48(6): 796-800.
Kannan R., Laboyka R., Low P.S. Isolation and characterization of the hemichrome-stabilized membrane protein aggregates from sickle erythrocytes. Major sites of autologous antibody binding. J. Biol. Chem. 1988, 263 (27): 13766-73.
Moreira-Rodrigues M., Henriques-Coelho Т., Moura C., Vasques-Novoa F., Sampaio-Maia В., Pestana M. et al. Cardiac dysfunction in HgCl2-induced nephrotic syndrome. Exp. Biol. Med. (Maywood). 2010; 235 (3): 392-400.
Williams Hematology / Kaushansky K. et al. 8th Edition. 2010: 777-799.
