Search for new bioactive compounds based on microbial transformation of oleanane type pentacyclic triterpenoids

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Published: Jul 21, 2024
DOI: https://doi.org/10.17072/1994-9952-2024-2-176-189
Keywords:
oleanolic acid glycyrrhetic acid microbial transformation biologically active compounds

Main Article Content

Natalia A. Plotnitskaya
Perm Federal Research Center of the Ural Branch of the Russian Academy of Science, Perm, Russia
Victoria V. Grishko
Perm Federal Research Center, Ural Branch of the Russian Academy of Sciences, Perm, Russia
Irina B. Ivshina
Perm Federal Research Center of the Ural Branch of the Russian Academy of Science, Perm, Russia

Abstract

Against the backdrop of a lack of highly effective pharmacological agents for the treatment of socially significant diseases, the search for new chemical compounds with biological activity based on plant pentacyclic triterpenoids, including oleanolic (OA) and glycyrrhetic (GA) acids, is urgent. These triterpene acids are used to obtain derivatives with pronounced antiviral, antimicrobial, anti-inflammatory, antitumor, and hepatoprotective activities. The transformation of triterpenoids is mainly carried out using chemical methods, requiring extreme acidity, temperature, the use of expensive catalysts or protective groups of the reactive centers of the molecule. This review presents the results of our own research and data from the scientific literature of recent years regarding the assessment of the possibility of using the biological transformation of OA and GA based on the enzymatic activity of microorganisms.

Article Details

How to Cite
Plotnitskaya Н. А. ., Grishko В. В. ., & Ivshina И. Б. . (2024). Search for new bioactive compounds based on microbial transformation of oleanane type pentacyclic triterpenoids. Bulletin of Perm University. Biology, (2), 176–189. https://doi.org/10.17072/1994-9952-2024-2-176-189
Issue
No. 2 (2024): Bulletin of Perm University. BIOLOGY
Section
Микробиология

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Author Biographies

Natalia A. Plotnitskaya, Perm Federal Research Center of the Ural Branch of the Russian Academy of Science, Perm, Russia

Researcher of the Laboratory of Alkanotrophic Microorganisms of the Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences, a branch of the Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences; assistant of the Department of Microbiology and Immunology of Perm State University

Victoria V. Grishko, Perm Federal Research Center, Ural Branch of the Russian Academy of Sciences, Perm, Russia

Candidate of chemistry, associate professor, head of the Laboratory of Biologically Active Compounds of the Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences, a branch of the Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences

Irina B. Ivshina, Perm Federal Research Center of the Ural Branch of the Russian Academy of Science, Perm, Russia

Doctor of biology, professor, academician of the Russian Academy of Sciences, head of the Laboratory of Alkanotrophic Microorganisms of the Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences, a branch of the Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences; professor of the Department of Microbiology and Immunology of Perm State University

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