Intermicrobial interactions in bacterial-fungal associations

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Published: Nov 5, 2024
DOI: https://doi.org/10.17072/1994-9952-2024-3-300-308
Keywords:
bacterial-fungal associations Aspergillus spp. Candida spp. Cryptococcus spp. exometabolites antagonism

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Marina V. Nikolenko
Tyumen State Medical University, Tyumen, Russia
Darya S. Sivkova
Tyumen State Medical University, Tyumen, Russia
Natalya V. Baryshnikova
Tyumen State Medical University, Tyumen, Russia
Lidiya V. Sorogina
Tyumen State Medical University, Tyumen, Russia

Abstract

One of the factors contributing to the increase in the incidence of mycoses is the formation of intermicrobial associations with opportunistic microbiota. Changing the balance in such communities may cause the emergence of other associated diseases. The influence of microorganisms on each other occurs through signaling molecules and exometabolites. Complex bacterial and fungal associations of pathogens of purulent-inflammatory infections are more difficult to respond to antimicrobial therapy and lead to a more severe clinical course or death. This review examines the features of bacterial-fungal interactions of Candida sрp., Aspergillus spp., Cryptococcus spр. According to literature, the decisive role in the virulent activity of fungi in bacterial-fungal associations is played by the species composition of associates involved in the development of the pathological process. In addition, it is necessary to take into account the quantitative ratio of microorganisms, as well as the degree of virulence of fungi, which increases significantly under the influence of metabolites of associated bacteria. Therefore, further study of fungal-bacterial associations is necessary to understand fundamental issues related to the evolution of microbial virulence and antimicrobial resistance. The interactions in the studied bacterial-fungal associations are very dynamic and diverse. The nature of the relationships between microorganisms affects not only survival, but also the virulence of each other.

Article Details

How to Cite
Nikolenko М. В. ., Sivkova Д. С. ., Baryshnikova Н. В., & Sorogina Л. В. . (2024). Intermicrobial interactions in bacterial-fungal associations. Bulletin of Perm University. Biology, (3), 300‒308. https://doi.org/10.17072/1994-9952-2024-3-300-308
Issue
No. 3 (2024): Bulletin of Perm University. BIOLOGY
Section
Микробиология

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Author Biographies

Marina V. Nikolenko, Tyumen State Medical University, Tyumen, Russia

doctor of biology, associate professor, professor of the Department of microbiology, Head of the Laboratory of microbiome, regenerative medicine and cell technologies

Darya S. Sivkova, Tyumen State Medical University, Tyumen, Russia

assistant at the Department of microbiology, junior researcher at the Laboratory of microbiome, regenerative medicine and cell technologies

Natalya V. Baryshnikova, Tyumen State Medical University, Tyumen, Russia

senior lecturer at the Department of microbiology

Lidiya V. Sorogina, Tyumen State Medical University, Tyumen, Russia

4th year student of the Institute of Clinical Medicine

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