Application of the method of pharmacoencephalography for the assessment of neuroprotective drug activity

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Published: Dec 23, 2022
DOI: https://doi.org/10.17072/1994-9952-2022-4-347-351
Keywords:
pharmacoencephalography neuroprotection rats

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Yuri I. Sysoev
Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia
https://orcid.org/0000-0003-4199-5318
Veronika A. Prikhodko
Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia
Daria D. Shits
Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia
Maria M. Puchik
Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia
https://orcid.org/0000-0003-1281-4354
Sergey V. Okovityi
Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia
https://orcid.org/0000-0003-4294-5531

Abstract

The search and study of new neuroprotective agents is an urgent task of biomedical research. Due to the low translational potential of the results of experimental and preclinical studies, new approaches are needed to evaluate the effectiveness of new compounds that have a positive effect on vascular or traumatic brain lesions. The method of pharmacoencephalography (pharmaco-EEG) is one of the neurophysiological research methods that allows you to assess the functional state of the brain in terms of its bioelectrical activity. Despite the need for surgical intervention, pharmaco-EEG in experimental neuroscience has several advantages over traditionally used behavioral tests, as well as biochemical or molecular genetic methods. This review considers examples of the use of this method to assess the neuroprotective activity of drugs in models of traumatic brain injury and stroke in rodents. However, based on the results of published studies, it can be concluded that pharmaco-EEG is a sensitive method for assessing the effects of drugs on the course of pathological processes in brain damage in rats and can be considered as a useful addition to traditional experimental approaches.

Article Details

How to Cite
Sysoev , Y. I. ., Prikhodko , V. A. ., Shits, D. D. ., Puchik, M. M. ., & Okovityi , S. V. . (2022). Application of the method of pharmacoencephalography for the assessment of neuroprotective drug activity. Bulletin of Perm University. Biology, (4), 347–351. https://doi.org/10.17072/1994-9952-2022-4-347-351
Issue
No. 4 (2022): Bulletin of Perm University. BIOLOGY
Section
Neurobiology

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Author Biographies

Yuri I. Sysoev , Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia

Cand. Sc. (Biol.), Associate Professor at the Department of Pharmacology and Clinical Pharmacology; Research Officer at the Laboratory of Neuroprosthetics; Senior Research Officer at the Laboratory of Neuromodulation of Motor and Visceral Functions; Research Officer at the Laboratory of Targeted Intra-Brain Drug Delivery

Veronika A. Prikhodko , Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia

Teaching Assistant at the Department of Pharmacology and Clinical Pharmacology; Junior Research Officer at the Laboratory of Targeted Intra-Brain Drug Delivery

Daria D. Shits, Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia

Student

Maria M. Puchik, Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia

Student

Sergey V. Okovityi , Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia

Dr. Sc. (Med.), Professor, Head of the Department of Pharmacology and Clinical Pharmacology; Head of the Laboratory of Targeted Intra-Brain Drug Delivery

References

Volokhova G.A., Stoyanov A.N. [Solcoseryl influence on brain trauma induced electrographic changes and behaviour in rats]. Meždunarodnyj nevrologičeskij žurnal. No 2 (2008): pp. 51-57. (In Russ.)

Gantsgorn E.V., Maklyakov Yu.S., Chloponin D.P. [Quantitative pharmaco-EEG analysis of the activity of nootropics and their combinations with melaxen in global cerebral ischemia in rats]. Biomedicina. No 3 (2015): pp. 87-94. (In Russ.)

Sysoev Yu.I., Kroshkina K.A., Okovityi S.V. [Characteristic of somatosensory evoked potentials in rats af-ter traumatic brain injury]. Rossijskij fiziologičeskij žurnal imeni I.M. Sečenova. V. 105, No 6 (2019a): pp. 749-760. (In Russ.). DOI: 10.1134/S0869813919060074.

Sysoev Yu.I. et al. [Neuroprotective activity of the alpha-2 adrenoreceptor agonist mafedine in a model of traumatic brain injury in rats]. Biomedicina. V. 15, No 1 (2019): pp. 62-77. (In Russ.). DOI: 10.33647/2074-5982-15-1-62-77.

Sysoev Yu.I. et al. [Changes in amplitude and spectral parameters of electrocorticograms in rats with traumatic brain injury]. Biomedicina. V. 15, No 4 (2019b): pp. 107-120. (In Russ.). DOI: 10.33647/2074-5982-15-4-107-120.

Sysoev Yu.I. et al. [Cross-correlation and coherence analysis of electrocorticograms of rats with traumatic brain injury]. Rossijskij fiziologičeskij žurnal imeni I.M. Sečenova. V. 106, No 3 (2020a): pp. 315-328. (In Russ.). DOI: 10.1007/s11055-020-01023-9.

Sysoev Yu.I. et al. [Changes in visual evoked potentials in rats with traumatic brain injury]. Biomedicina. V. 16, No 2 (2020b): pp. 68-77. (In Russ.). DOI: 10.33647/2074-5982-16-2-68-77.

Berger C. et al. Neuroprotection by pravastatin in acute ischemic stroke in rats. Brain Research Reviews. V. 58, No 1 (2008): pp. 48-56. DOI: 10.1016/j.brainresrev.2007.10.010.

Iino M. et al. Real-time PCR quantitation of FE65 a beta-amyloid precursor protein-binding protein after traumatic brain injury in rats. International Journal of Legal Medicine. V. 117, No 3 (2003): pp. 153-159. DOI: 10.1007/s00414-003-0370-y.

Li Y., Zhang J. Animal models of stroke. Animal Models and Experimental Medicine. V. 4, No 3 2021. P. 204–219. DOI: 10.1002/ame2.12179

Marklund N., Hillered L. Animal modeling of traumatic brain injury in preclinical drug development: where do we go from here? Brazilian Journal of Pharmacology. V. 164, No 4 (2011): pp. 1207-1229. DOI: 10.1111/j.1476-5381.2010.01163.x.

Schallert T. Behavioral tests for preclinical intervention assessment. NeuroRx. V. 3, No. 4 (2006): pp. 497-504. DOI: 10.1016/j.nurx.2006.08.001.

Sysoev Yu.I. et al. Effects of alpha-2 adrenergic agonist mafedine on brain electrical activity in rats after traumatic brain injury. Brain Sciences. V. 11, No 8 (2021): pp. 981. DOI: 10.3390/brainsci11080981.

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