Effect of Phenazepam on Behavioral Patterns in Rats

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Published: Dec 23, 2022
DOI: https://doi.org/10.17072/1994-9952-2022-4-335-339
Keywords:
behavior rats phenazepam anxiolytic anxiety «open field»

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Oksana V. Agafonova
Perm State University, Perm, Russia
Eduard Korkotian
The Weizmann Institute of Science, Rehovot, Israel
https://orcid.org/0000-0001-5515-3387

Abstract

Due to the development of information technology, many researchers have received access to the latest methods in the observation, recording, and analysis of various kinds of data arrays. Thus, machine analysis based on new algorithms facilitates the comparison of different patterns of behavior, including the study of the dynamics of animal activity under the influence of neurotropic drugs, an example of which is phenazepam. The aim of our study was to use computer analysis systems to compare the behavior patterns of two groups of laboratory rats: the control group and the group following phenazepam, as well as to study the overall effect of phenazepam on the behavior of rats. As the study showed, features were revealed in the level of expression of the general trajectories of rat movement during the testing. In addition, the use of home-developed color time coding techniques, made it possible to detect the existence of a correlation in behavior between two time positions of the same animal. The scope of the methods developed by us is not limited to scientific and laboratory practice. Some of these methods are applicable to humans, especially patients suffering from a wide range of neurological and motor disorders.

Article Details

How to Cite
Agafonova, O. V. ., & Korkotian, E. . (2022). Effect of Phenazepam on Behavioral Patterns in Rats. Bulletin of Perm University. Biology, (4), 335–339. https://doi.org/10.17072/1994-9952-2022-4-335-339
Issue
No. 4 (2022): Bulletin of Perm University. BIOLOGY
Section
Neurobiology

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Author Biographies

Oksana V. Agafonova, Perm State University, Perm, Russia

Master of the Department of Pharmacology and Pharmacy

Eduard Korkotian, The Weizmann Institute of Science, Rehovot, Israel

Doctor of Philosophy, Head of Confocal Microscopy Division

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