Study and comparative evaluation of the toxicity of molybdenum (VI) oxide nanoparticles at a single oral exposure

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Published: Nov 11, 2022
DOI: https://doi.org/10.17072/1994-9952-2022-3-241-249
Keywords:
molybdenum (VI) oxide nanoparticles microparticles oral exposure bioaccumulation pathomorphologycal changes

Main Article Content

Nina V. Zaitseva
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia
https://orcid.org/0000-0003-2356-1145
Marina A. Zemlyanova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia
https://orcid.org/0000-0002-8013-9613
Mark S. Stepankov
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia
https://orcid.org/0000-0002-7226-7682
Anna M. Ignatova
Institute of Continuous Media Mechanics, Perm, Russia
https://orcid.org/0000-0001-9075-3257
Anastasiya A. Dovbysh
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia
Anna V. Nedoshytova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia
https://orcid.org/0000-0001-6514-7239
Marina V. Volkova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia
https://orcid.org/0000-0002-0600-4075

Abstract

The toxic effect of nanoparticles of molybdenum (VI) oxide (MoO3 NPs) after a single oral intake was studied. We administered the test substance as an aqueous suspension at a dose of 2000 mg/kg body weight. Organs were taken from surviving animals 14 days after exposure to study the bioaccumulation of MoO3 NPs and pathomorphological changes caused by the action of this nanomaterial. On the second day after exposure, the death of 50% of the group exposed to NPs was recorded. It has been established that MoO3 NPs accumulate in the heart, lungs, liver, kidneys and brain in concentrations 15.59-221.86 times higher than the control values. In the liver of exposed rats revealed by histological methods the development of hepatitis and microvesicular steatosis; in the lungs – acute bronchitis, vasculitis; in the brain – subarachnoid hemorrhage. MoO3 NPs have a more apparent ability to bioaccumulate and produce toxic effects in comparison with their microdispersed analogue under single oral introductions into the body.

Article Details

How to Cite
Zaitseva Н. В. ., Zemlyanova М. А. ., Stepankov М. С., Ignatova А. М., Dovbysh А. А., Nedoshytova А. В., & Volkova М. В. (2022). Study and comparative evaluation of the toxicity of molybdenum (VI) oxide nanoparticles at a single oral exposure. Bulletin of Perm University. Biology, (3), 241–249. https://doi.org/10.17072/1994-9952-2022-3-241-249
Issue
No. 3 (2022): Bulletin of Perm University. Biology
Section
Ecology

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Author Biographies

Nina V. Zaitseva, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia

Doctor of medicine, academician of RAS, Scientific Director

Marina A. Zemlyanova, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia

Doctor of medicine, head of Department of Biochemical and Cytogenetic Diagnostics, professor of Department of Microbiology and Immunology of PSU, professor of Department of Environmental Secure of PNRPU

Mark S. Stepankov, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia

Junior researcher of Department of Biochemical and Cytogenetic Diagnostics

Anna M. Ignatova, Institute of Continuous Media Mechanics, Perm, Russia

Doctor of technical science, researcher of laboratory of physical foundations of strength

Anastasiya A. Dovbysh , Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia

Toxicologist of Department of Biochemical and Cytogenetic Diagnostics;

Anna V. Nedoshytova, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia

Researcher of Department of Analytical Chemistry Analysis

Marina V. Volkova, Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia

Researcher of Department of Analytical Chemistry Analysis

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