Аларамоны как фактор персистенции бактерий

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Опубликован: дек 15, 2023
DOI: https://doi.org/10.17072/1994-9952-2023-4-356-366
Ключевые слова:
персистенция бактерий резистентность к антибиотикам алармоны (p)ppGpp дормантность RSH ингибиторы алармонсинтетаз

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Роман Сидоров
Институт экологии и генетики микроорганизмов, Пермский федеральный исследовательский центр Уральского отделения Российской академии наук
Александр Ткаченко
Институт экологии и генетики микроорганизмов, Пермский федеральный исследовательский центр Уральского отделения Российской академии наук

Аннотация

Лечение бактериальных инфекций антибиотиками существенно осложняется вследствие адаптивных механизмов, которые используют бактерии. Хронические и рецидивирующие инфекции часто связаны с такими процессами, как бактериальная персистенция, образование биопленок и толерантность к антибиотикам. Эти явления приводят к снижению метаболической активности, что делает бактерии нечувствительными к обычным антибиотикам, которые преимущественно оказывают воздействие на активно растущие клетки. Стринджент-ответ, регулируемый алармонами (p)ppGpp, является механизмом адаптации к стрессу, консервативным для многих бактериальных видов, и играет ключевую роль в обеспечении долговременного выживания при дефиците питательных веществ. Алармоны (p)ppGpp также имеют важное значение в формировании бактериальной персистенции и биопленок. Поиск новых антибактериальных препаратов, специфически нацеленных на подавление синтеза (p)ppGpp, и, таким образом, ингибирующих стринджент-ответ, представляет собой многообещающую стратегию в борьбе с бактериальными инфекциями. В этом контексте ингибиторы алармонсинтетаз являются перспективными кандидатами для клинического применения, поскольку они демонстрируют эффективность в подавлении механизмов выживания бактерий, уменьшают образование биопленок и сниженают толерантность к антибиотикам и персистенцию бактерий.

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Как цитировать
Сидоров R. Y., & Ткаченко A. G. (2023). Аларамоны как фактор персистенции бактерий. Вестник Пермского университета. Серия Биология, (4), 356–366. https://doi.org/10.17072/1994-9952-2023-4-356-366
Выпуск
№ 4 (2023): Вестник Пермского университета. Серия Биология
Раздел
Микробиология

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Биографии авторов

Роман Сидоров, Институт экологии и генетики микроорганизмов, Пермский федеральный исследовательский центр Уральского отделения Российской академии наук

Инженер лаборатории адаптации микроорганизмов, младший научный сотрудник лаборатории органического синтеза

Александр Ткаченко, Институт экологии и генетики микроорганизмов, Пермский федеральный исследовательский центр Уральского отделения Российской академии наук

Д-р мед. наук, профессор, зав. лаборатории адаптации микроорганизмов, профессор кафедры микробиологии и иммунологии

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